Cell Metric

Solentim Ltd.

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Solentim Ltd. has announced the Cell Metric cell imaging and analysis instrument. Engineered as a high-throughput work-flow solution to screen for colonies from single-cell cloning experiments, it uses proprietary nonimage-based focusing to locate all possible colonies by imaging the whole well, right up to the edge.

The platform provides complete and accurate cell measurements, without removing the cells from the culture plate and without adding stains or dyes, ensuring that cells are suitable for use in downstream experiments. The system can identify every healthy viable cell clone from large multiwell screening projects and can track the visual history of the colonies back to single cells.

The proprietary imaging technology overcomes the problems of shadowing and edge effects. Colonies tend to form around the edge of the wells, and researchers have reported that previously they were missing 10% to 20% of their potentially high value clones. The new system addresses this problem and ensures that the colonies are not missed, according to the company.

It is programmed to provide real-time, user-defined metrics on the cell number, confluence or density, colony count and variations in cell morphology, including viability and mitotic index, and can rapidly process samples in lidded 6-, 12-, 24-, 96- and 384-well microplates. Linking the Cell Metric system with a robotic arm and plate stacker provides a complete walk-away solution, with environmental control for large plate numbers and multiuser projects, or where longer-term growth and kinetic studies are required.

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Published: June 2011