Request InfoNikon Instruments Inc.Nikon Instruments Inc.’s N-SIM superresolution microscope is based on structured illumination (SIM) technology developed and licensed to Nikon by the University of California, San Francisco. Used in conjunction with total internal reflection fluorescence microscopy, the technology allows the microstructures and nanostructures of fixed and living cells to be viewed with molecular-scale resolution, achieving twice the resolution of conventional optical microscopes, even near the cell membrane. It achieves a time resolution of 0.6 s per frame.See full productRelated content from Photonics MediaPRODUCTSBioPhotonics Sep/Oct 2023 IssueUpright MicroscopeThe ECLIPSE Ui integrated microscope-based viewing system from Nikon Instruments Inc. is designed for clinical and pathological observation. The system provides a digital user experience,...Promoted Content March 2024 IssueUltra-Precision Microscopy DemoThe Nucleus™ microscopy platform provides a complete set of interchangeable hardware modules and software tools, making it ideal for OEMs and lab managers engaged in fluorescence cellular...Photonics Spectra October 2023 IssueMultiphoton Confocal MicroscopeThe AX R MP super-resolution multiphoton confocal microscope with the Nikon Spatial Array Confocal (NSPARC) detector is designed for observing deep areas within large living organisms with high...Promoted Content June 2023 IssueNanopositioning for High-Res MicroscopyPI's new Fast Focus Stages and Multi-Axis Piezo Flexure Scanners for Microscopy are designed to improve the performance of high-resolution microscopy. Choice of piezo and voice coil motors....ARTICLESBioPhotonics Jan/Feb 2024 IssueAlgorithm Targets Microscope ResolutionScientists have used various approaches to improve spatial resolution in fluorescence microscopy. Deconvolution, in which images are numerically deblurred based on a knowledge of the...Photonics Spectra February 2024 IssueAlgorithm Boosts Live-Cell Imaging's CapabilitiesSuperresolution radial fluctuations (SRRF), a superresolution algorithm, works by observing fluctuations in radial symmetry throughout the frames of an image. SRRF supports live-cell, superresolution...BioPhotonics.com March 2024 IssueDMD-Based SIM Attains Fast Superresolution Bioimaging in 3DAlthough structured illumination microscopy (SIM) demonstrates ultrahigh temporal and spatial resolution, the speed and intricacy of polarization modulation affect the speed and quality of its...Photonics.com 2/23/2024SPAD Elevates Spatiotemporal Resolution in Conventional MicroscopesImage scanning microscopy (ISM), a superresolution technique enabled by the advent of fast and compact detector arrays, provides signal-to-noise ratio (SNR), optical sectioning, and spatial...PHOTONICS HANDBOOK ARTICLESPhotonics HandbookSuperresolution Microscopy: An Imaging RevolutionSuperresolution optical microscopy, for which the Nobel Prize was awarded to Eric Betzig, Stefan Hell, and William Moerner in 2014, has been one of the most momentous developments in the life...Photonics HandbookLasers for Microscopy: Major TrendsLaser development for the microscopy market continues to be driven by key trends in applications, which currently include superresolution techniques, multiphoton applications in optogenetics and...Photonics HandbookAspheric Lenses: Design ConsiderationsAspheric surfaces are powerful tools that combine the optical corrections of multiple lenses into a single element (Figure 1) and affect performance in ways that spherical optics cannot. For example,...Photonics HandbookNanopositioning: A Step AheadBy its original definition, a nanopositioning device is a mechanism capable of repeatedly delivering motion in increments as small as one nanometer. Lately demands from industry and research have...WHITEPAPERSPhotonics.com 4/20/2023Is a DIY Microscope for You?For some advanced microscopy and nanoscopy techniques it becomes necessary to modify existing instrumentation or build an instrument from scratch. This article helps readers determine whether a...Photonics.com 10/4/2022Product Development Strategies for Electro-Optical SystemsThis whitepaper looks at the unique challenges associated with optical systems by exploring two extremes, an ultra-high precision instrument, and a low-cost consumer product, and the different...Photonics.com 5/24/2022Medical Optics from Shanghai OpticsProducing optics for medical devices has its own unique set of difficulties and challenges including cost, turnaround time, performance, and standards. This paper talks about those challenges and...Photonics.com 12/8/2022Sub 50 Femtosecond Pulse Lasers for Gentler Multiphoton MicroscopyFinding the ideal ultra-fast laser source for a multiphoton imaging setup is not trivial. It is a fine balance between peak power, pulse energy and laser wavelength. In this white paper we show that...WEBINARSPhotonics.com 10/25/2018Shareable Advanced Light-Sheet Microscopy Using FlamingoThis webinar will discuss a new model for advanced microscopy, based on shareable, modular instruments. This model, called Flamingo, is designed to bridge the gap between biology and technology....Photonics.com 3/21/2013Techniques in Biophotonic ImagingFREE WEBINAR Sponsored by: Hamamatsu & Applied Scientific Instrumentation Additional Questions & Answers from the webinar are below: Dr. Kimani C. Toussaint Jr. Quantitative...Photonics.com 6/11/2015Biophotonic Imaging for Medicine: A Digital ConferenceResearchers from around the world presented their latest work at “Biophotonic Imaging for Medicine: A Digital Conference.” Presentations focused on a range of light-based imaging and...Photonics.com 12/14/2011The Future of Imaging: Three PerspectivesPresenters: Professor Stephen Boppart The Future of Healthcare With Optical Biomedical Imaging A medical doctor and professor at the University of Illinois, Boppart's...PHOTONICS DICTIONARY+ TERMSPhotonics Dictionaryphoton jetA photon jet is a narrow, highly collimated beam of light that is formed when light interacts with small dielectric microstructures, such as microspheres or microcylinders. This phenomenon arises due...Photonics DictionarysuperresolutionSuperresolution refers to the enhancement or improvement of the spatial resolution beyond the conventional limits imposed by the diffraction of light. In the context of imaging, it is a set of...Photonics Dictionaryswept source optical coherence tomographySwept-source optical coherence tomography is an imaging technique used in medical diagnostics, particularly in ophthalmology, to visualize and analyze the internal structures of biological tissues,...Photonics Dictionarylensless microscopyLensless microscopy, also known as computational or holographic microscopy, is an imaging technique that captures and reconstructs microscopic images without the use of traditional lenses. Instead of...VIDEOSPhotonics.com 2/21/2018Photonics on the Showroom Floor and in the Lab - LIGHT MATTERS 02.2018On this month's episode of Light Matters, we take you on a brief tour of the Higgins Laboratories at Worcester Polytechnic Institute (WPI). Quinsigamond Community College and WPI received a $4M grant...Photonics.com 1/5/2017Sneak Preview: Photonics West: The Most Wonderful Time of the [Industry’s] YearThree conferences and two exhibitions make SPIE Photonics West the world’s largest annual event in the industry. From plenary presentations to networking opportunities, this show offers an expansive,...Photonics.com 1/10/2017Photonics West Blends Industry, Innovation, LearningPhotonics West is an annual must-attend event in the photonics industry and for more than two decades it has been a symbol of the optimism and excitement for the potential of photonics and...Photonics.com 2/23/2017Photonics West 2017 Ushers in the New Year - LIGHT MATTERS 02.2017Photonics Media followed the photons all the way to San Francisco earlier this month for SPIE’s Photonics West 2017. The year truly begins with this event for many in the industry, as it is a symbol...PHOTONICS BUYERS' GUIDE CATEGORIESMicroscopy NanotechnologyOptical Thin-Film Design ServicesNanotechnology Imaging SystemsUltraviolet MicroscopesAn ultraviolet microscope is a microscope used either to detect selective absorption of various wavelengths by the specimen or to achieve increased resolution by virtue of the short wavelength of...COMPANIESPhotonics Buyers' GuideShanghai Optics Inc.ISO 9001 & ISO 13485 certified and D&B DUNS # 113515303 Shanghai Optics is an unparalleled custom system solution provider offering advance precision custom optical design, engineering,...Photonics Buyers' GuideOptikos CorporationThe Optical Engineering Experts® Optikos designs and manufactures metrology products for measuring and assuring optical image quality; and provides optical engineering design, development,...Photonics Buyers' GuideCASTECH INC.CASTECH is a recognized leading supplier of nonlinear optical crystals, laser crystals and precision optical components for laser, telecom, medical, analysis and detector markets. Products...Photonics Buyers' GuideFOCtek Photonics Inc.FOCtek provides customers with all types of custom manufactured lenses, Precision Optical Components, Polarizing Optics, Prisms, Filters, Coatings, Optical Systems, Crystals, Nonlinear Crystals,...