Part of the “Bioinformatics & Biomedical Imaging” series, the book Systems Bioinformatics: An Engineering Case-Based Approach introduces a quantitative systems approach to bioinformatics research using computational tools drawn from signal processing, circuit analysis, control systems and communications. The 404-page resource discusses how the knowledge bases of various technical disciplines are observed in biological systems. It addresses signal processing techniques that are important in biological data analysis, including biomedical imaging and image processing, feature extraction and estimation. Chapters cover areas such as cryptography, chemotaxis, control and system fundamentals, modeling cellular networks, applied cellular engineering, Bayesian networks for genetic analysis, design for synthetic biology and DNA/RNA sequence hybridization. Charts, diagrams, references, an index and a companion CD-ROM are provided. Gil Alterovitz and Marco F. Ramoni, eds.; Artech House Inc., Norwood, Mass., 2007; $99.