BRIDGEWATER, N.J., March 18, 2010 – Hamamatsu Corp.’s ORCA-Flash2.8, a digital camera based on a scientific CMOS image sensor, is designed for low-light imaging at high frame rates. The FL-280 sensor features 2.8 megapixels and a pixel size of 3.63 × 3.63 µm. Wavelength sensitivity ranges from the UV to the visible, with peak sensitivity and >60% quantum efficiency at ~450 to 500 nm. Typical readout noise is 3 electrons rms, even at fast readout speeds. Producing low dark current, it requires cooling to only 5 °C. The camera’s readout speed ranges from 45 fps at full resolution to 1273 fps with subarray readout. Features include external trigger, real-time corrections and analog gain. The camera is designed for quantitative measurements with 12-bit output, and it interfaces with a PC via the included Camera Link frame grabber. Applications include ratio imaging; Förster resonance energy transfer, fluorescence in situ hybridization and total internal reflection fluorescence microscopy; real-time confocal microscopy; semiconductor inspection; and industrial imaging.