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  • Mobility Instrument
Mar 2010
Wyatt Technology Corp.Request Info
SANTA BARBARA, Calif., March 29, 2010 — Wyatt Technology Corp. has launched the Möbius instrument for fast, reliable and noninvasive measurements of macromolecular electrophoretic mobilities.

The laser-based device provides reproducible measurements of mobilities of liposomes, viruslike particles and protein samples, including antibody formulations, bovine serum albumin (BSA) and lysozyme. Through parallelism of detection, it measures in <1 min, provides sufficient data to average away molecular diffusion and extends the measurable molecular size range below 2 nm. The reduced measurement time preserves fragile protein samples.

Detection sensitivity is 2 mg/ml for lysozyme and 0.5 mg/ml for BSA. Simultaneous measurement of the macromolecular hydrodynamic radius is available with the WyattQELS (quasielastic light scattering) option, which uses backward scattered light to determine the sample translational diffusion coefficient.

Reusable flow-through cells and disposable cells are offered for mobility and QELS measurements. Samples can be introduced by manual injection, an autosampler, a syringe pump or an autotitrator. The system offers temperature control and performs automated temperature studies.

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