Wyatt Technology Corp. has launched the Möbiuζ, a laser-based instrument for noninvasive measurement of macromolecular electrophoretic mobilities. The device provides reproducible data on the mobilities of large particles such as liposomes and viruslike particles and of protein samples that are hard to measure, including antibody formulations, bovine serum albumin (BSA) and lysozyme. Through parallelism of detection, it measures in <1 min, preserving fragile protein samples and providing sufficient data to average away molecular diffusion and extend the measurable molecular size range below 2 nm. Detection sensitivity is 2 mg/ml for lysozyme and 0.5 mg/ml for BSA. Simultaneous measurement of the macromolecular hydrodynamic radius is available with the WyattQELS (quasielastic light scattering) option, which uses backward scattered light to determine the sample translational diffusion coefficient.