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  • Illumination Microscopy
May 2010
Leica Microsystems GmbHRequest Info
WETZLAR, Germany, May 27, 2010 — Resolution and contrast are crucially important for fluorescence applications in wide-field microscopy. Undesired haze effects that reduce contrast can be minimized by using the smart principle of structured illumination, which results in fluorescence images with good contrast, high axial resolution and ultrasharp 2-D sections of the specimen.

Intelligent Structured Illumination Microscopy from Leica Microsystems uses the proven OptiGrid technique. Working in harmony with the company’s high-quality optics, the aperture diaphragm integrated with the fluorescence light path also enhances contrast. The automatic focus function of the OptiGrid keeps the grid structure in focus, from UV to IR light.

The same OptiGrid module can be used both for upright and inverted Leica research microscopes, and there is no need to change the grid because one optimized grid covers all magnifications from 10× to 100×, offering convenience, avoiding errors and saving valuable time.

Intelligent Structured Illumination Microscopy provides a complete system from a single source: The OptiGrid module integrated with Leica research microscopes is controlled by intuitive and proprietary MM AF software and complemented by a wide selection of fluorescence cameras.


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aperture diaphragm
The second adjustable iris diaphragm in an optical system. In the common microscope condenser system, it usually is located beneath the substage condenser on a transmitted light microscope. When the aperture diaphragm is adjusted, the intensity of the light and the angle of the cone of light entering the objective are varied. Also refers to the iris in a camera lens.
The emission of light or other electromagnetic radiation of longer wavelengths by a substance as a result of the absorption of some other radiation of shorter wavelengths, provided the emission continues only as long as the stimulus producing it is maintained. In other words, fluorescence is the luminescence that persists for less than about 10-8 s after excitation.
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