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ARI Nano Dispense Head

Photonics.com
Aug 2010
Rigaku Americas Corp.Request Info
 
CARLSBAD, Calif., Aug. 24, 2010 — Rigaku Americas Corp. and Art Robbins Instruments have announced that all Phoenix RE (Rigaku Edition) protein drop setters will now be equipped with a new nano-dispense head, the ARI nano, that offers significant benefits over previous models, including improved dispense accuracy of proteins, improved washing and expanded service life of the dispense needles.

These improvements are due to a flow-through design combined with a pump and two reservoirs that enable better washing of the needles. With this new design, the ARI nano, in addition to air-backed dispensing, also performs liquid-backed dispensing that delivers accuracy for highly viscous proteins and that dispenses volumes below 100 nl. The nano-dispense head can be configured with up to four channels.

The Phoenix RE is a modified Art Robbins Instruments Phoenix liquid handler that is used to set up protein crystallization plates. Featuring a positive displacement 96-channel head to dispense the screens, and a noncontact nano dispenser to dispense the protein, the Phoenix RE employs an accurate closed-loop motion to produce the drop-on-drop dispenses required for protein crystallography.

Protein crystals are required for protein crystallography, which is a core structural biology technique that uses x-ray diffraction to obtain 3-D structures of proteins and protein complexes. Protein structures provide detailed insight into fundamental biological processes in support of understanding disease mechanisms and the rational drug design process. When incorporated into a Rigaku CrystalMation system, the Phoenix RE can be used for fully automated high-throughput protein crystal production.


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GLOSSARY
x-ray diffraction
The bending of x-rays by the regular layers of molecules in a crystal acting like a very small diffraction grating. The diffraction pattern so obtained and recorded on film provides a means for analyzing the crystal structure.  
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