The BX3, an upright research microscope system from Olympus Europa Holding GmbH, allows users to define their own working environments: from the microscope and imaging components to software work flows and GUIs to the positioning of the controls on the desktop. The manual BX53 frame offers system flexibility with optional coded and automated modules, and the BX63 frame provides advanced automation as standard. The microscope is combined with an imaging module, a camera and cellSens software. A programmable touch-panel control simplifies observation and imaging tasks and can be placed wherever the user wants. It controls all of the components of the imaging system, enabling users to change the objective, mirror unit and observation method, as well as to navigate and focus the sample.