Request InfoNikon Instruments Inc.Nikon Instruments Inc.’s N-SIM superresolution microscope is based on structured illumination (SIM) technology developed and licensed to Nikon by the University of California, San Francisco. Used in conjunction with total internal reflection fluorescence microscopy, the technology allows the microstructures and nanostructures of fixed and living cells to be viewed with molecular-scale resolution, achieving twice the resolution of conventional optical microscopes, even near the cell membrane. It achieves a time resolution of 0.6 s per frame.See full productRelated content from Photonics MediaPRODUCTSBioPhotonics Sep/Oct 2023 IssueUpright MicroscopeThe ECLIPSE Ui integrated microscope-based viewing system from Nikon Instruments Inc. is designed for clinical and pathological observation. The system provides a digital user experience,...Photonics Spectra October 2023 IssueMultiphoton Confocal MicroscopeThe AX R MP super-resolution multiphoton confocal microscope with the Nikon Spatial Array Confocal (NSPARC) detector is designed for observing deep areas within large living organisms with high...BioPhotonics Sep/Oct 2023 IssueOptical Stereo MicroscopesThe third-generation range of Mantis ergonomic optical stereo microscopes from Vision Engineering Ltd. feature improved optics for hand-to-eye coordination and depth perception. The microscopes...BioPhotonics May/Jun 2023 IssueMonochrome Microscope CameraThe Digital Sight 50M monochrome microscope camera from Nikon Instruments Inc. conducts high-precision analysis and large-volume sampling for use in applications such as well plate screening. ...ARTICLESBioPhotonics Jan/Feb 2024 IssueAlgorithm Targets Microscope ResolutionScientists have used various approaches to improve spatial resolution in fluorescence microscopy. Deconvolution, in which images are numerically deblurred based on a knowledge of the...BioPhotonics Jan/Feb 2024 IssueLabel-Free Imaging Shows Dynamics of Intracellular Cargo TransportUntil now, scientists have relied on fluorescence microscopy techniques to study intracellular cargo transport, a vital process to maintaining essential cellular functions. However, the effects of...Photonics Spectra January 2024 IssueVirtual Superlens Passes Diffraction Limit Without DistortionThe diffraction limit enforces physical restrictions on how closely an object can be examined using traditional optical methods. Previous attempts to develop superlenses that image beyond the...Photonics.com 2/23/2024SPAD Elevates Spatiotemporal Resolution in Conventional MicroscopesImage scanning microscopy (ISM), a superresolution technique enabled by the advent of fast and compact detector arrays, provides signal-to-noise ratio (SNR), optical sectioning, and spatial...PHOTONICS HANDBOOK ARTICLESPhotonics HandbookLasers for Microscopy: Major TrendsLaser development for the microscopy market continues to be driven by key trends in applications, which currently include superresolution techniques, multiphoton applications in optogenetics and...Photonics HandbookSuperresolution Microscopy: An Imaging RevolutionSuperresolution optical microscopy, for which the Nobel Prize was awarded to Eric Betzig, Stefan Hell, and William Moerner in 2014, has been one of the most momentous developments in the life...Photonics HandbookNanopositioning: A Step AheadBy its original definition, a nanopositioning device is a mechanism capable of repeatedly delivering motion in increments as small as one nanometer. Lately demands from industry and research have...Photonics HandbookAspheric Lenses: Design ConsiderationsAspheric surfaces are powerful tools that combine the optical corrections of multiple lenses into a single element (Figure 1) and affect performance in ways that spherical optics cannot. For example,...WHITEPAPERSPhotonics.com 10/4/2022Product Development Strategies for Electro-Optical SystemsThis whitepaper looks at the unique challenges associated with optical systems by exploring two extremes, an ultra-high precision instrument, and a low-cost consumer product, and the different...Photonics.com 4/20/2023Is a DIY Microscope for You?For some advanced microscopy and nanoscopy techniques it becomes necessary to modify existing instrumentation or build an instrument from scratch. This article helps readers determine whether a...Photonics.com 1/10/2024Single-Objective Light SheetAn overview of the Single-Objective Light Sheet.Photonics.com 9/27/2023Raman SpectroscopyTo achieve accurate and precise Raman measurements, optical filters play a crucial role in enhancing signal-to-noise ratio, and reducing background interference. This white paper explores the...WEBINARSPhotonics.com 10/25/2018Shareable Advanced Light-Sheet Microscopy Using FlamingoThis webinar will discuss a new model for advanced microscopy, based on shareable, modular instruments. This model, called Flamingo, is designed to bridge the gap between biology and technology....Photonics.com 3/21/2013Techniques in Biophotonic ImagingFREE WEBINAR Sponsored by: Hamamatsu & Applied Scientific Instrumentation Additional Questions & Answers from the webinar are below: Dr. Kimani C. Toussaint Jr. Quantitative...Photonics.com 10/26/2022Fluorescence Techniques Help Preserve Parathyroid Function During Thyroid SurgeryHypoparathyroidism is the most common complication after total thyroidectomy and is the result of the inadvertent devascularization of parathyroid glands. To help address this issue, researchers have...Photonics.com 6/11/2015Biophotonic Imaging for Medicine: A Digital ConferenceResearchers from around the world presented their latest work at “Biophotonic Imaging for Medicine: A Digital Conference.” Presentations focused on a range of light-based imaging and...PHOTONICS DICTIONARY+ TERMSPhotonics Dictionaryphoton jetA photon jet is a narrow, highly collimated beam of light that is formed when light interacts with small dielectric microstructures, such as microspheres or microcylinders. This phenomenon arises due...Photonics DictionarysuperresolutionSuperresolution refers to the enhancement or improvement of the spatial resolution beyond the conventional limits imposed by the diffraction of light. In the context of imaging, it is a set of...Photonics Dictionarytwo-photon polymerizationTwo-photon polymerization (TPP) is a technique used in additive manufacturing, specifically in the field of 3D printing. It involves using a focused laser to polymerize a photosensitive material in a...Photonics Dictionaryspectral domain optical coherence tomographySpectral domain optical coherence tomography is an imaging technique used in medical diagnostics, particularly in ophthalmology, to visualize and analyze the internal structures of biological...VIDEOSPhotonics.com 1/5/2017Sneak Preview: Photonics West: The Most Wonderful Time of the [Industry’s] YearThree conferences and two exhibitions make SPIE Photonics West the world’s largest annual event in the industry. From plenary presentations to networking opportunities, this show offers an expansive,...Photonics.com 2/21/2018Photonics on the Showroom Floor and in the Lab - LIGHT MATTERS 02.2018On this month's episode of Light Matters, we take you on a brief tour of the Higgins Laboratories at Worcester Polytechnic Institute (WPI). Quinsigamond Community College and WPI received a $4M grant...Photonics.com 2/23/2017Photonics West 2017 Ushers in the New Year - LIGHT MATTERS 02.2017Photonics Media followed the photons all the way to San Francisco earlier this month for SPIE’s Photonics West 2017. The year truly begins with this event for many in the industry, as it is a symbol...Photonics.com 1/10/2017Photonics West Blends Industry, Innovation, LearningPhotonics West is an annual must-attend event in the photonics industry and for more than two decades it has been a symbol of the optimism and excitement for the potential of photonics and...PHOTONICS BUYERS' GUIDE CATEGORIESMicroscopy NanotechnologyOptical Thin-Film Design ServicesNanotechnology Imaging SystemsOptical Design and Engineering ServicesOptical design and engineering services involve the development, customization, and optimization of optical systems and components to meet specific performance requirements and application needs....COMPANIESPhotonics Buyers' GuideShanghai Optics Inc.ISO 9001 & ISO 13485 certified and D&B DUNS # 113515303 Shanghai Optics is an unparalleled custom system solution provider offering advance precision custom optical design, engineering,...Photonics Buyers' GuideOptikos CorporationThe Optical Engineering Experts® Optikos designs and manufactures metrology products for measuring and assuring optical image quality; and provides optical engineering design, development,...Photonics Buyers' GuideFOCtek Photonics Inc.FOCtek provides customers with all types of custom manufactured lenses, Precision Optical Components, Polarizing Optics, Prisms, Filters, Coatings, Optical Systems, Crystals, Nonlinear Crystals,...Photonics Buyers' GuideCASTECH INC.CASTECH is a recognized leading supplier of nonlinear optical crystals, laser crystals and precision optical components for laser, telecom, medical, analysis and detector markets. 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