The W130i from Avid Nano is a high-sensitivity dynamic light-scattering system for size and molecular weight measurement of proteins, biomolecules and nanoparticles. Suitable for use in research laboratories, the system measures 5 μl of sample in seconds. Features include a benchtop footprint, rugged durability and ease of use. Integrated into the system is the proprietary SABRe stabilized anti-backreflection optical design that renders it permanently mechanically stable and immune to reflections. The patent-pending 5-μl BladeCell cuvette combines the convenience of a disposable sample holder with the measurement quality of a quartz cuvette. Built-in compatibility with standard fluorescence cuvettes and flow cells renders the W130i versatile. Applications include crystal screening, buffer optimization, solubility screening, aggregate detection, micelle formation, engineered nanoparticles and formulation development.