ROCKLAND, Mass., Oct. 20, 2011 — Prior Scientific Inc. has released LumenLED, an illumination system for fluorescence microscopy. It offers two modes of operation, enabling the LEDs to be optimized for specific applications. In “constant light” mode, a photodiode provides a closed-loop feedback mechanism to ensure short- and long-term stability of illumination intensity, essential for quantitative experiments. For more general imaging applications, “constant current” mode assures maximum illumination intensity. The modular system is based on a two- or four-position LED combiner directly coupled to the fluorescence port of the microscope to maximize light efficiency and to avoid the light loss associated with fiber guides. The system can be mounted onto most major manufacturers’ inverted or upright microscopes using the appropriate adapters. Up to 10 LED modules are available, mounted in the combiner and providing up to four LED wavelengths. LED modules are exchanged in a matter of seconds, so it is easy to modify the illumination source to match the application. Fast shuttering is standard, thanks to the nature of LEDs, and a ≥10,000-h lifetime eliminates the need for bulb replacement and alignment while minimizing operating costs. Imaging software that already supports the company’s filter wheels and shutters can be used to operate the LumenLED, and a software development kit is provided to facilitate software integration where more advanced features may be required.