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fluorescence microscopy News
Optofluidic Device Tests for Blood Disorders at Point of Care
HARBIN, China, Jan. 25, 2024 — Abnormalities in white blood cell count are indicative of a blood disorder. Measuring these abnormalities is imperative. However, the use of flow cytometry and other conventional methods to assess white blood cell concentration is confined to hospital and laboratory settings due to the bulkiness and complexity of the equipment. Access to such equipment in remote areas presents challenges in terms of early diagnosis for patients. Portable blood cell analyzers could alleviate these
Label-Free Imaging Shows Dynamics of Intracellular Cargo Transport
DAEJEON, South Korea, Nov. 22, 2023 — Until now, scientists have relied on fluorescence microscopy techniques to study intracellular cargo transport, a vital process to maintaining essential cellular functions. However, the effects of photobleaching and the visual isolation of cellular...
Light-Activated Tool Controls Protein Bonds and Tracks Cell Adhesion
TAMPERE, Finland, Nov. 20, 2023 — Optical tools can be used to activate biological functions, but with current methods the effects are slow to appear, and sustained effects require continuous light activation. As a result, these light-activation tools provide limited control of fast...
Algorithm Targets Microscope Resolution
BOSTON, Nov. 16, 2023 — Scientists have used various approaches to improve spatial resolution in fluorescence microscopy. Deconvolution, in which images are numerically deblurred based on a knowledge of the microscope’s point spread function, is one approach....
Fluorescence Lifetime Imaging Could Improve Cancer Surgery Outcomes
BOSTON, Oct. 24, 2023 — Extreme precision is required to surgically remove a cancerous tumor without damaging the surrounding healthy tissue. Yet surgeons often must rely on their eyes and hands to determine where to cut. Fluorescence lifetime (FLT) imaging, developed at...
Microscopy Method Uses Infrared Light to Image Molecules with Vibrational Contrast
PASADENA, Calif., July 7, 2023 — The complementary strengths of fluorescence and vibrational microscopy are combined in a new technique developed at Caltech, which is called bond-selective fluorescence-detected infrared-excited spectro-microscopy (BonFIRE). BonFIRE will benefit...
Nobel Prize-Winning Techniques Help Resolve Imaging Challenge
ITHACA, N.Y., Oct. 27, 2022 — Using a technique that was recently awarded the 2022 Nobel Prize in chemistry, researchers at Cornell University used expansion microscopy to study lipids, the water-repellent, dynamic components that comprise the walls of cells and organelles. The...
Imaging System Speeds Diagnosis with Real-Time Biopsy Analysis
ROCHESTER, N.Y., Oct. 13, 2022 — Results of a pilot study conducted at the University of Rochester showed that a system based on two-photon fluorescence microscopy (TPFM) enabled rapid diagnosis of nonmelanoma skin cancer through real-time imaging of unprocessed, fresh tissue...
Eikon Therapeutics Raises $518M, Completes Recruitment of Leadership Team
HAYWARD, Calif., Jan. 10, 2022 — Eikon Therapeutics, a company focused on the application of superresolution microscopy to drug discovery, closed a $517.8 million Series B financing round. Since its founding, Eikon Therapeutics has raised more than $688 million. The company has...
Optochemical Storage System Cuts Costs, Resists Data Corruption
CAMBRIDGE, Mass., Oct. 25, 2021 — Fluorescent dyes could play a central role in the quest for optical methods to ensure reliable and cost-effective data storage. A Harvard University research team has devised a way to store digital data in fluorescent dye molecules, using...
Optical Method Enables Drug Toxicological Assessments in Early-Stage Tests
GENOA, ITALY, Oct. 11, 2021 — An Italian Institute of Technology (IIT)-coordinated project has received €3 million ($3.47 million) from the European Union to develop a biosensor based on a novel virtual mirror design. Researchers said the biosensor will be able to detect...
Lens-Free Fluorescence Microscope to Achieve High Throughput, Resolution
LEUVEN, Belgium, July 5, 2021 — A fluorescence microscope being developed by imec researchers will be able to achieve high throughput and high resolution, without a lens component. The technology could significantly speed up next-generation DNA sequencing and cellular research, as...
Lattice Light-Sheet Microscopy Targets Malaria
MELBOURNE, Australia, June 22, 2021 — With the help of a custom-built lattice light-sheet microscope, researchers at the Walter and Eliza Hall Institute (WEHI) captured high-resolution 3D video images of individual malaria parasites (Plasmodium falciparum) invading red blood cells in...
Microscopy Method Resolves Fluorescence at Nanometer Scale
GÖTTINGEN, Germany, March 24, 2021 — Researchers led by Stefan Hell at the Max Planck Institute (MPI) for Biophysical Chemistry and the Heidelberg-based MPI for Medical Research have developed a light microscopy method, MINSTED, that is able to resolve fluorescently labeled details...
Multiphoton Microscopy Protocol Reveals Breast Cell Function, Behavior Inside Living Tissue
PARKVILLE, Australia, March 3, 2021 — A team from the Walter and Eliza Hall Institute of Medical Research in Australia has shown the ability to image tissue cells in the breast, without harming them, to observe their behavior at microscopic levels. The team used multiphoton microscopy,...
Improving Microscope Resolution with Plasmonic Metasurfaces
FUKUOKA, Japan, Nov. 9, 2020 — While imaging cells using real-time fluorescence microscopy methods, professor Kaoru Tamada of Kyushu University’s Institute for Materials Chemistry and Engineering and her group found that they could improve resolution under a conventional...
3D Visualization Method Reveals Molecular Position, Orientation, Oscillations
ROCHESTER, N.Y., Oct. 26, 2020 — Researchers at the University of Rochester and the Fresnel Institute in France developed a method for visualizing molecules’ position and orientation in 3D, as well as their oscillations. The technique could allow for greater insights into the...
Image Scanning Microscopy Technique Extends Beyond Limits
WARSAW, Poland, Oct. 22, 2020 — A collaboration between researchers at the University of Warsaw and the Weizmann Institute of Science yielded a method of fluorescence microscopy that, in theory, has no resolution limit. In practice, the team demonstrated a fourfold improvement...
Imaging Flow Cytometry and Microscopy Combine to Identify Pollen
LEIPZIG, Germany, Oct. 8, 2020 — Collaborating scientists from the Helmholtz Centre for Environmental Research (UFZ) and the German Centre for Integrative Biodiversity Research (iDiv) developed an image-based particle analysis system, reliant upon laser light and AI, to automate...
Imaging Method Enables Research on Abundant Cellular Protein Actin
LA JOLLA, Calif., Aug. 11, 2020 — Researchers at the Salk Institute have developed a new imaging method that allows them to monitor actin, a small subset of skeleton-like filaments within cells. The method has enabled research on how actin mediates an important function: helping...
Company of Biologists, 'Journal of Cell Science' Launch FocalPlane
CAMBRIDGE, England, Aug. 3, 2020 — The Company of Biologists and Journal of Cell Science have created a web-based community resource for microscopists and biologists to share microscopy news, events, and resources. The site is free to access, and users may register for a free account...
Methodology Aids Microscopic Study of Fibrils in Molecules
ST. LOUIS, July 14, 2020 — Researchers from Washington University in St. Louis have found a mechanism to efficiently and accurately measure the point spread functions (PSFs) of the position of molecules, called variance upper bound (VUB). They believe this will someday aid...
NIH Researchers Speed Image Processing for Fluorescence Microscopy
BETHESDA, Md., July 9, 2020 — Advances in image processing techniques could reduce post-processing time for highly complex microscopic images up to several thousandfold, based on work done by a research team at the National Institutes of Health (NIH) and their collaborators at...
Olympus Announces Light Microscopy Image Awards
WALTHAM, Mass., March 27, 2020 — Olympus has announced the winners of its first Global Image of the Year Life Science Microscopy Award. The winning image, captured by Ainara Pintor of Spain using a superresolution confocal microscope system. The image shows the immunostaining of a...
Fluorogenic Method Detects Two-Protein Aggregation in Live Cells
STATE COLLEGE, Pa., Feb. 15, 2019 — A new method uses fluorescence to detect potentially disease-causing forms of proteins as they misfold and unravel due to stress or mutations. Researchers from Pennsylvania State University (Penn State) and the University of Washington re-engineered...
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