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proteins News
Signal Enhancement Enables Study of Label-Free Proteins
MARSEILLE, France, Jan. 26, 2023 — Researchers at Institut Fresnel have developed a technique to detect the ultraviolet-autofluorescence signal in single proteins, opening the way for the label-free study of thousands of proteins whose natural fluorescence cannot be detected using existing technology. Though proteins are fluorescent in the UV because they contain tryptophan amino acids, most proteins have only one to five tryptophan — which is too few to provide a strong UV signal at the level required for label-free
Expansion Microscopy Technique Reveals Hidden Nanostructures
CAMBRIDGE, Mass., Sept. 6, 2022 — Proteins and other molecules are often tightly packed together inside a living cell. These dense clusters can be difficult to image because the fluorescent labels used to make them visible can’t wedge themselves in between the molecules....
Biosensor Barcodes Track Cancer Cell Communications
BALTIMORE, Dec. 7, 2021 — Johns Hopkins University researchers have developed a method for identifying and tracking cells in a manner similar to the way barcodes are used to identify and track products. The team used the method to study the way that cancer cells...
Biobased Method Could Extract Domestic Supply of Rare-Earth Elements
STATE COLLEGE, Pa., Oct. 26, 2021 — An eco-friendly way to extract and separate rare earth elements (REEs) from unconventional sources has been demonstrated by researchers at Penn State and Lawrence Livermore National Laboratory (LLNL). The method relies on a bacterial protein that is...
Raman Spectroscopy Platform Delivers Insights on Intrinsically Disordered Proteins
HONG KONG, April 30, 2021 — Researchers from the Hong Kong University of Science and Technology (HKUST) developed optical tweezers-coupled Raman spectroscopy that can directly probe the structural features of alpha-synuclein, an intrinsically disordered protein (IDP) that is...
UCF’s Kyu Young Han Receives NIH Grants
ORLANDO, Fla., Nov. 4, 2020 — Kyu Young Han, assistant professor in the University of Central Florida (UCF) College of Optics and Photonics, has been awarded two grants from the National Institutes of Health (NIH). The first is a Maximizing Investigator’s Research Award...
Penn State's Wang Receives NSF Award for Biomarker Research
STATE COLLEGE, Pa., Sept. 12, 2018 — Yong Wang, professor of biomedical engineering at Penn State, has received a National Science Foundation (NSF) award of some $320,000 to develop a technology that will more easily and accurately visualize trace biomarker proteins under a microscope....
Interferometric Technique Targets Protein Shadows
ERLANGEN, Germany, Sept. 24, 2014 — A new optical method for targeting proteins could mean earlier diagnosis and more effective treatment for cancer.
Transparency Allows Better Diagnostic Imaging
PASADENA, Calif., Aug. 6, 2014 — New diagnostic medical applications could be in the pipeline, allowing scientists to better image developmental problems and disease within the human body. It is now possible to see through the entire human body, including its tissues and organs,...
Optogenetic Switch Now Works Both Ways: On and Off
STANFORD, Calif., April 24, 2014 — Since the beginning of optogenetics, the technique has been more effective at switching neurons on than off -- but not anymore. Building from Dr. Karl Deisseroth’s discovery about a decade ago of optogenetics — in which light-activated...
Imaging System Offers Clearer Tissue Visualization
WALTHAM, Mass., March 5, 2014 — Studying proteins and disease markers could get easier, thanks to a new high-throughput imaging system called Lamina.
Single-Cell Imaging Clarifies How Cells Tell Time
COLUMBUS, Ohio, and MONTREAL, Nov. 19, 2012 — A new imaging approach offers the first real-time visual evidence of how cells know when to enter the next phase of their development.
Biomimetic Antenna May Transform Solar Devices
ST. LOUIS, Dec. 5, 2011 — A newly developed light-harvesting antenna modeled on the chlorosome found in green bacteria could transform solar-powered devices and give silicon and printed dye photovoltaics a run for their money. The invention of the solar cell in 1941...
New Imaging Tech Diagnoses Multiple Diseases
WEST LAFAYETTE, Ind., June 13, 2011 — By measuring ultrasound signals from molecules exposed to a fast-pulsing laser, biomedical engineers at Purdue University developed an imaging technology that diagnoses multiple diseases.
Genetic tags illuminate life
SAN DIEGO – A new type of genetic tag made by modifying a plant protein has the potential to illuminate life in never-before-seen detail. Scientists from the University of California, San Diego (UCSD), School of Medicine have re-engineered a...
New Superresolution Technique Reveals Cell Secrets
ALBUQUERQUE, N.M., May 18, 2011 — A new superresolution microscopy technique is answering longheld questions about how and why a cell’s defenses fail against some invaders, such as plague, while successfully fending off others, such as E. coli. The approach is revealing...
Polarized Microscopy Shows Protein Position
NEW YORK, April 21, 2011 — A new polarization-based technique can help deduce the orientation of specific proteins within a cell. By turning their instruments toward the nuclear pore complex — a huge cluster of proteins that serves as a gateway to a cell's nucleus...
Glowing Nanopillars Light Up Cells
STANFORD, Calif., April 14, 2011 — A novel cellular research platform created at Stanford University uses nanopillars that glow in such a way as to allow a deeper and more precise look into living cells. The Stanford team — led by chemist Bianxiao Cui and engineer Yi Cui (no...
Luciferase Aids Blood Clot Detection
NEW LONDON, Conn., Feb. 11, 2011 — The enzyme that makes fireflies glow is lighting up the scientific path toward a long-sought new medical imaging agent to better monitor treatment with heparin, the blood thinner that millions of people take to prevent or treat blood clots. In a...
Revealing How Cells Die
BUFFALO, N.Y., Aug. 27, 2010 — Apoptosis, or programmed cell death, is essential to normal development, healthy immune system function and cancer prevention. The process dramatically transforms cellular structures, but the limitations of conventional microscopy methods have kept...
Bright Boost for Fluorescent Probes
PITTSBURGH, Aug. 26, 2010 – Researchers from Carnegie Mellon University’s Molecular Biosensor and Imaging Center (MBIC) are turning up the brightness on a group of fluorescent probes called fluoromodules that are used to monitor biological activities of individual...
Photothermal imaging detects nanorod orientation
HOUSTON – “Fluorescence vector probes and polarization-sensitive single-molecule spectroscopies have been widely used to explore the conformation dynamics of proteins in biological systems – and an ideal probe should yield high signal with low...
Simpler, more cost-effective biosensing
GÖTEBORG, Sweden – There are two challenges facing optical label-free biosensing, especially for clinical applications, according to Alexandre Dmitriev of Chalmers University of Technology.< “The system should be able to work in physiological fluids –...
Autoprobing Tech for Fast Diagnoses
SANKT AUGUSTIN, Germany, March 22, 2010 — The Fraunhofer Institute for Applied Information Technology (FIT) has developed a fully automated high-performance microscope with which researchers will be able to study the complex interactions of proteins between cells.
Optical microrings boost cancer detection
URBANA-CHAMPAIGN, Ill. – Sensitive detection of biomolecules is of great interest for applications such as drug development, virus detection, environmental monitoring and medical diagnostics. In contrast to optical biosensors based on surface plasmon resonance,...
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April 2024
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