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Nanoparticles Enable Drug Activation by NIR Light

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SINGAPORE, Sept. 28, 2012 — Nanoparticles that convert near-infrared to ultraviolet or visible light could help overcome the skin penetration limits of conventional photodynamic therapy. Photodynamic therapy (PDT) uses visible light — usually in the red wavelength — to activate a light-sensitive drug but is limited to a penetration depth of about 1 cm. Because of this, PDT is currently used to treat certain types of cancer just under the skin, such as in the esophagus. It generally can’t be used to treat cancers that have spread or large tumors. The new technique, developed at the National...Read full article

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    Published: September 2012
    Glossary
    nano
    An SI prefix meaning one billionth (10-9). Nano can also be used to indicate the study of atoms, molecules and other structures and particles on the nanometer scale. Nano-optics (also referred to as nanophotonics), for example, is the study of how light and light-matter interactions behave on the nanometer scale. See nanophotonics.
    photodynamic therapy
    A medical technology that uses lasers or other light sources in combination with photosensitizing drugs to treat cancerous tumors.
    photonics
    The technology of generating and harnessing light and other forms of radiant energy whose quantum unit is the photon. The science includes light emission, transmission, deflection, amplification and detection by optical components and instruments, lasers and other light sources, fiber optics, electro-optical instrumentation, related hardware and electronics, and sophisticated systems. The range of applications of photonics extends from energy generation to detection to communications and...
    Asia-PacificbiomarkersBiophotonicscancer imagingdeep cancergene expression in micegene expression manipulationlight-based therapiesmesoporous silicananonanoparticlesNational University of Singaporenear-infrared lightNIRnoninvasive photodynamic therapyphotodynamic therapyphotonicsResearch & TechnologySingaporeultraviolet lightup-conversionup-conversion nanoparticlesUV lightvisible lightZhang Yong

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