A new optical approach could help doctors quickly determine a patient’s blood coagulation status in near real time. A team at Massachusetts General Hospital has developed an optical device that requires only a few drops of blood and just a few minutes to measure the key coagulation parameters that can guide medical decisions, such as how much blood to transfuse or what doses of anticoagulant drugs to administer. Laser speckle patterns captured from a human blood sample show time-dependent speckle intensity modulation during coagulation. 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