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Optogenetic Tool Efficiently Manipulates Protein Clusters

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An optogenetic technique dubbed CRY2clust is able to trigger protein cluster formation in response to blue light at a faster and more efficient rate than existing methods. CRY2clust is based on a photoreceptor protein called cryptochrome 2 (CRY2), and more specifically, on a part of CRY2 known as CRY2 Photolyase Homology Region (CRY2PHR), which causes this protein to assemble in response to the blue portion of sunlight. In this optogenetic system, CRY2 (blue and pink) clustering is reversibly controlled by blue light. If CRY2 is linked to fluorescent proteins (green), the clustering...Read full article

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