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Probing Cancer by Exploiting Spontaneous and Stimulated Raman Scattering

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A hybrid system creates an analytical tool that enables the discovery of hidden signatures in cancer cells.

CHIEN-SHENG LIAO, WELDON SCHOOL OF BIOMEDICAL ENGINEERING, PURDUE UNIVERSITY, AND JI-XIN CHENG, WELDON SCHOOL OF BIOMEDICAL ENGINEERING, PURDUE UNIVERSITY, AND THE PHOTONICS CENTER, BOSTON UNIVERSITY

Most of our knowledge about the chemical contents in cancer cells or cancerous tissue is obtained from in vitro analysis of fixed cells and tissues or homogenates. These in vitro assays identify the presence of molecules, but do not provide information about their spatial distribution or temporal dynamics. A detailed mapping of molecules in live cells or intact tissues would pave the way for disease-specific drug developments or better marker-based diagnosis. Raman scattering, an inelastic scattering process first reported in the 1920s by C.V. Raman and others, enables label-free,...Read full article

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