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Quantitative Phase Imaging Aims at Penetrating Thick Tissues

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Innovations using multiple scattering illuminate specimens not penetrable by earlier technologies.

FRANCISCO E. ROBLES, GEORGIA INSTITUTE OF TECHNOLOGY, EMORY UNIVERSITY

In 1942, phase microscopy revolutionized biological imaging because it enabled clear visualization of cells and their internal contents without labels or stains. This empowered biologists to study these transparent, living objects over long periods without killing them or altering their function or dynamic behavior1,2. Today, quantitative phase imaging (QPI), an extension of phase microscopy, is a very active area of research that has led to many advancements in biology, including quantification of cellular structures below a nanometer, the characterization of cell mass transport and minute...Read full article

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