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Ultrashort-Pulse Lasers: Emerging Tools for Biomedical Discovery

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From intracellular surgery to vision correction, ultrashort-pulse lasers play a critical behind-the-scenes role for today’s clinicians.

FAROOQ AHMED, CONTRIBUTING EDITOR

From nonsurgical vision correction to multiphoton imaging to neuronal optogenetics, ultrashort-pulse lasers — also informally known as ultrafast lasers — have become essential tools in biomedical discovery. VEGFR3-positive (red) lymphatic vessels in diaphragm whole-mount section. Collagen fibers were visualized by second-harmonic generation (SHG) (green). Scale bar = 100 µm. Courtesy of Friedemann Kiefer, European Institute for Molecular Imaging. The technology that led to the development of these lasers reached a breakthrough in the mid-1980s when...Read full article

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