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MICROSCOPY FEATURES
Raman Imaging Opens View to Diagnosis and Discovery Aug 13, 2020 — By revealing the chemical composition of samples, Raman microscopy has proved to be useful in many fields, including medical diagnosis, materials science, cosmetics, and food science. For the researcher, clinician, or engineer, it is most useful because it is a nondestructive method and requires no staining or other specialized sample preparation. The Raman effect describes the inelastic scattering of excitation light by molecules. The interaction of a molecule with photons causes vibrations of...
BioPhotonics, Oct 2020
Portable Microscopy Leverages Advancements in Electronics and Computing Aug 12, 2020 — Spurred by Moore’s law, the principle that the number of transistors on a microchip doubles every two years, the miniaturization of electronic components has resulted in optical devices shrinking as well. While etendue (a characteristic of light and...
BioPhotonics, Oct 2020
The Microscope Enters the Digital Age Feb 5, 2020 — Within the field of pathology, the upright light microscope is perhaps the most ubiquitous piece of equipment used for examination. Found on every pathologist’s desk, the glass and light device plays a central role in disease diagnosis, displaying...
BioPhotonics, Apr 2020
Imaging Technology, Experimentation Converge at SPIE BiOS Dec 18, 2019 — A host of researchers and industry experts will descend on SPIE BiOS 2020 in February to expound upon — and demonstrate — the ability of optical technologies to analyze, diagnose, and treat a multitude of medical conditions that clinicians grapple...
BioPhotonics, Feb 2020
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Advancements in Holography Usher In Sci-Fi-Inspired Devices Dec 3, 2019 — The 1971 Nobel Prize in physics was awarded to the Hungarian-British electrical engineer Dennis Gabor for inventing the field of holography. It wasn’t until six years later, however, that the discipline would gain widespread recognition. In...
Photonics Spectra, Jan 2020
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Digital Holographic Microscopy Enhances Cytometry and Histology Oct 29, 2019 — In recent years, quantitative phase imaging (QPI) has been continuously improved for purposes of high-resolution, label-free quantitative microscopy. Label-free imaging has received increased attention in the last decade as a minimally invasive way...
EuroPhotonics, Dec 2019
The Eyes Behind Surgical Robots Oct 22, 2019 — The first robotic surgery took place in 1985 when the PUMA 560 was used in a stereotaxic operation in which computed tomography (or x-ray) was used intraoperatively to guide a robot as it inserted a needle into the brain for biopsy. In the late...
Photonics Spectra, Apr 2020
Deconvolution Helps Break Down Imaging Barriers Oct 11, 2019 — Deconvolution is a computationally intensive image processing technique used to improve the contrast and sharpness of images captured with a light microscope. Light microscopes are diffraction limited, which means they are unable to resolve...
BioPhotonics, Dec 2019
Open-Source Photon Counting Advances Biological Research Aug 8, 2019 — A surgeon removing a malignant tumor, a security agent detecting harmful molecules at a stadium, an autonomous car avoiding a collision, a weather satellite spotting hurricane formations, a neuroscientist tracking neuronal activity deep within the...
BioPhotonics, Sep 2019
Multispectral Imaging Aids Wound Healing, Pathology Research Jun 11, 2019 — From airborne mapping to astronomical imaging to manufacturing inspection, multispectral imaging (MSI) has long been the go-to tool for extracting crucial details, often from distant views. Today, MSI is making promising inroads in biomedical...
BioPhotonics, Aug 2019
Custom Optical Coatings for Cinema, Avionics, and LIGO Apr 12, 2019 — Commercial off-the-shelf (COTS) optical components such as filters, beamsplitters, prisms, and mirrors are used in numerous applications, including machine vision, microscopy, and optical test and measurement. These components are often coated with...
Photonics Spectra, May 2019
LASER World of PHOTONICS 2019: An Innovation Playground Apr 10, 2019 — With a first-rate portfolio, LASER World of PHOTONICS (Laser Munich) is a one-stop shop for research and technology, industry, and academia — showcasing numerous photonics components, systems, and applications. The biennial conference and...
BioPhotonics, Jun 2019
Ultrashort-Pulse Lasers: Emerging Tools for Biomedical Discovery Mar 15, 2019 — From nonsurgical vision correction to multiphoton imaging to neuronal optogenetics, ultrashort-pulse lasers — also informally known as ultrafast lasers — have become essential tools in biomedical discovery. VEGFR3-positive (red)...
BioPhotonics, Apr 2019
Upconversion Materials Empower Thermal Bioimaging Mar 8, 2019 — Bioimaging is a fundamental technique for research in the life sciences, and it is used routinely in the medical industry. The procedure itself encompasses many different methods, such as electron microscopy, x-ray tomography, and magnetic resonance...
BioPhotonics, Apr 2019
Member Exclusive
Novel Multiphoton Imaging Techniques Reveal Brain’s Secrets Jan 11, 2019 — Nearly two decades ago, Winfried Denk and Karel Svoboda argued in the journal Neuron that “multiphoton imaging is more than a gimmick”1. At the time, confocal microscopy — combined with advancements in fluorescent reporter systems...
BioPhotonics, Mar 2019
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Advancements in Raman Spectroscopy Find Real-World Uses in the Life Sciences Dec 14, 2018 — Since its development in the mid-1920s, Raman spectroscopy has been used to study various low-frequency vibrational modes in molecular systems. In contrast to its counterpart — Fourier transform infrared spectroscopy (FTIR), which probes...
BioPhotonics, Jan 2019
Optimizing Probe Positioning for Life Science Research Oct 12, 2018 — Photonics technologies enable life scientists to probe samples in the increasingly sophisticated study of processes ranging from neuron signaling to heart muscle contraction, as well as cells and cellular development. As research continues at...
BioPhotonics, Dec 2018
Miniaturization, Increased Resolution Drive Microscopy’s Future Sep 12, 2018 — Miniature fluorescence microscopes and other system components, such as liquid lenses, are among emerging microscopy advancements that are bettering optical inspection in areas including the life sciences and machine vision. Now, such technology is...
BioPhotonics, Oct 2018
SHG Microscopy Brings Live Cells into 3D Focus Sep 10, 2018 — Second-harmonic generation (SHG) microscopy brings the imaging of select biomolecular assemblies into 3D focus. It highlights biomolecules that follow specific structural organization within biological tissues, and complements two-photon excited...
BioPhotonics, Oct 2018
Photothermal IR Spectroscopy Boosts Chemical Microscopy, Expands Applications Aug 15, 2018 — Current bioanalysis largely relies on tissue homogenization and separation, followed by various assays. Without spatial and temporal dynamics information, the way in which molecules execute their functions in a living system remains unknown....
BioPhotonics, Sep 2018
Fluorescence Microscopy Unravels Morphogenesis, Function of Lymph System May 24, 2018 — The lymphatic system is an underinvestigated part of the vascular system. A team led by Friedemann Kiefer at the European Institute for Molecular Imaging (EIMI) at the University of Münster in Germany is aiming to change that in ongoing studies...
BioPhotonics, Aug 2018
Double-Helix Point Spread Function Delivers Precise Extended-Depth Microscopy May 23, 2018 — Light microscopy is a powerful method used in many scientific disciplines, including the life sciences, to visualize finer details in samples. The use of fluorescence enables specific targeting and labeling of biomolecules and other chemicals....
BioPhotonics, Aug 2018
Continuously Variable Bandpass Filters Aid Optics and HSI May 14, 2018 — Hyperspectral imaging (HSI) has been in use for a couple of decades in applications such as satellite imaging and air reconnaissance. Despite its widespread use, there is a lack of clarity of what “hyperspectral” encompasses. Sometimes techniques...
Photonics Spectra, Jun 2018
Nonconfocal 3D Microscopy Combines Real-Time Images with Depth of Focus Apr 9, 2018 — Stereo 3D microscopes produce real-time 3D images, but they are usually limited to low-magnification applications, such as dissection. Most compound light microscopes produce flat, 2D images because high-magnification microscope lenses have...
BioPhotonics, Jun 2018
Multiphoton Microscopy Sets the Standard for Live-Cell Imaging Mar 12, 2018 — Multiphoton imaging is widely used for live-cell imaging. Many of the applications are in neuroscience, where the overarching trends involve deeper imaging using longer wavelengths. These trends are the leading drivers behind the latest generation...
BioPhotonics, Apr 2018
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