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MICROSCOPY FEATURES
A Multiphoton Microscope Enables Portable 3D Biological Imaging Sep 16, 2022 — For decades, optical microscopy has provided the mechanism with which to image cells and tissue for the purposes of cancer research, digital pathology, and the study of the brain. Samples are typically studied in frozen sections. Most of these systems use confocal microscopy and single-photon excitation, typically from a continuous-wave light source, to probe the sample. Multiphoton microscopy is used when deep-tissue and cellular-level resolution are desired to preserve the image of the tissue...
BioPhotonics, Oct 2022
Sputter-Coated Optics Improve Machine Vision and Remote Sensing Jul 13, 2022 — For biomedical instrumentation applications such as fluorescence microscopy and Raman spectroscopy, sputter-coated thin-film interference filters deliver exemplary performance. These filters also enhance imaging system performance for applications...
Photonics Spectra, Sep 2022
Single-Photon Avalanche Diodes Sharpen Spatial and Temporal Resolution Mar 31, 2022 — As their name implies, single-photon avalanche diodes (SPADs) detect single particles of light, and they do so with picosecond precision. Single-pixel SPADs have found wide use in astronomy, flow cytometry, fluorescence lifetime imaging microscopy...
Photonics Spectra, May 2022
AI Bridges the Gap Between Medical Imaging and Analysis Feb 18, 2022 — Improvements in the automation of functional mechanical, electrical, and optical components — along with increasing computing power for image analysis — have enabled the development of high-throughput microscopes, such as the whole slide scanners...
BioPhotonics, Jun 2022
LEDs and Optical Filters Expand Live-Cell Imaging Capability Feb 7, 2022 — The light source of a wide-field fluorescence microscope is often overlooked by scientists who perform live-cell imaging experiments. However, innovations such as transistor-transistor logic (TTL) triggering, which enhances on/off speed, and inline...
BioPhotonics, Apr 2022
The Biophotonics Congress Will Explore Image Analysis and Wearable Monitoring Feb 3, 2022 — The upcoming Biophotonics Congress: Biomedical Optics will feature optical technologies ranging from spectroscopy and endoscopy for the diagnosis of disease to computational pathology and wearable sensors that monitor vital health statistics. The...
BioPhotonics, Apr 2022
Photoacoustic Remote Sensing Reveals Clues About Cancer, Blindness Jan 6, 2022 — As microscopic optical inspection techniques have progressed over the years, they have provided valuable insights into the composition, structure, and function of cells and subcellular structures, transforming the way researchers and clinicians look...
BioPhotonics, Apr 2022
Quantum Cascade Lasers Shift from an Emerging to an Enabling Technology Jan 5, 2022 — Since the unveiling of the quantum cascade laser (QCL) at Bell Labs in 1994, the technology has evolved — from being simply a cutting-edge field in pho­tonics research to being commercially available in the form of packaged lasers, QCL-powered...
Photonics Spectra, Feb 2022
Multiphoton Exoscope Broadens Noninvasive Imaging of Skin Dec 9, 2021 — Skin imaging at the cellular level is critical for understanding how diseases and aging affect the skin, and for developing strategies and therapies to prevent and combat these effects in a clinical setting. Visualizing dynamic cellular and...
BioPhotonics, Feb 2022
Miniaturization in NIR Spectroscopy Reshapes Chemical Analysis Nov 24, 2021 — Near-infrared (NIR) spectroscopy has been used in groundbreaking research in many of the life sciences due to its capacity to rapidly determine and analyze the composition of materials. Bulky instruments with limited portability, however, have kept...
BioPhotonics, Feb 2022
Scientific Cameras Push the Boundaries of Speed and Sensitivity Nov 24, 2021 — Scientific applications push imaging to the extremes. They demand cameras that can capture events as they unfold over nanoseconds, or capture processes that produce only a few photons across a broad spectrum — or a combination of both. In all...
Photonics Spectra, Jan 2022
Neurophotonic Techniques Shed New Light on Traumatic Brain Injury Oct 20, 2021 — Traumatic brain injury can have catastrophic impacts on everyday functioning and quality of life. Now, a set of photonic tools may provide fresh insights into this condition. Along with the technical knowledge made available by the application of...
BioPhotonics, Dec 2021
Biomedical Research, Innovation to Take Center Stage at SPIE BiOS Oct 20, 2021 — A rapid-fire Hot Topics session featuring talks on the latest in biomedical optics, from live analysis of embryonic development to deep learning-enabled optics, will be a centerpiece at SPIE BiOS — part of Photonics West 2022 — to be...
BioPhotonics, Dec 2021
Two-Photon Imaging Monitors Brain Synapses During Prolonged Anesthesia Oct 15, 2021 — The formation of synapses in the circuitry of the brain, and especially the solidification and disappearance of synaptic structures, mediates how people learn, memorize, and forget. Since the introduction of two-photon imaging to neuroscience in the...
BioPhotonics, Dec 2021
The BioPhotonics Conference Sep 30, 2021 — Photonics Media will host the first-ever BioPhotonics Conference online Oct. 26-28. Experts in microscopy, spectroscopy, OCT, flow cytometry, and medical lasers will present on topics such as the detection of cancer and viruses, the analysis of...
BioPhotonics, Oct 2021
Ultrafast Lasers Excite Advancements in Multiphoton Imaging Sep 30, 2021 — Multiphoton microscopy can image deeper into tissue than traditional confocal microscopy, making it ideal for a range of life science studies. The technique is crucial for brain-related research because it allows imaging of large numbers of neurons...
Photonics Spectra, Nov 2021
Camera Selection for Low-Light Imaging Apr 30, 2021 — Fluorescence microscopy is a broadly used term, with applications ranging from basic life science, such as time-lapse cell viability assays, to sophisticated techniques in which a very few photons or single molecules are detected and localized by...
Photonics Spectra, Jun 2021
Microscopy Technique Enhances 3D Imaging Capability Feb 11, 2021 — Optical microscopes use light to visualize detailed structures of small samples. The most popular microscopy technique for biological or biomedical studies by far is wide-field microscopy, in which a sample, such as tissue, is imaged through a...
BioPhotonics, Apr 2021
Multiplex Imaging Captures Cellular Processes Jan 5, 2021 — Ongoing innovations in optical microscopy have fueled life science research, allowing scientists to visualize how complex biological systems work and break down. These developments have required specifications beyond the need for high-resolution...
BioPhotonics, Jun 2021
Light Sheet Microscopy Enables 3D Pathology Dec 29, 2020 — Pathology for cancer diagnosis today relies on manual processing and an individual’s assessment of 2D samples. While this method has been established for over a century, the process has limitations. It can introduce inter-observer variability, and...
BioPhotonics, Jun 2021
Superresolution Microscopy Analysis Accelerated by Machine Learning Sep 4, 2020 — Superresolution optical microscopy — a technology that enables the acquisition of fluorescent micrographs of samples with a resolution well below the optical diffraction limit of ~250 nm — is rapidly evolving. Several methods have been developed...
BioPhotonics, Apr 2021
Raman Imaging Opens View to Diagnosis and Discovery Aug 13, 2020 — By revealing the chemical composition of samples, Raman microscopy has proved to be useful in many fields, including medical diagnosis, materials science, cosmetics, and food science. For the researcher, clinician, or engineer, it is most useful...
BioPhotonics, Oct 2020
Portable Microscopy Leverages Advancements in Electronics and Computing Aug 12, 2020 — Spurred by Moore’s law, the principle that the number of transistors on a microchip doubles every two years, the miniaturization of electronic components has resulted in optical devices shrinking as well. While etendue (a characteristic of light and...
BioPhotonics, Oct 2020
Microscopic Methods Reveal Holistic Picture of Sample Jun 11, 2020 — Whole slide imaging is a method principally employed when scientists need to image a large, relatively two-dimensional sample that expands beyond a single microscope field of view. Typical applications include imaging of histological tissues that...
BioPhotonics, Aug 2020
Diffuser Modulation Enables Quantitative Lensless Microscopy Jun 9, 2020 — Traditional optical microscopes require constant adjustments to bring a sample into focus. To see a small feature with details, researchers must use a high-resolution objective lens with a reduced field of view. The trade-off between resolution and...
BioPhotonics, Aug 2020
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