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superresolution News
AO-LLSM Microscope Achieves Aberration-Free Imaging
ASHBURN, Va., April 23, 2018 — Scientists have combined lattice light-sheet microscopy (LLSM) with adaptive optics (AO) to capture high-resolution 3D movies of cells deep within living systems. The AO-LLSM microscope enables cells to be viewed in their native multicellular environments, under as gentle illumination as possible, with minimal external perturbation. The microscope could create new opportunities to study the diversity of intracellular dynamics, extracellular communication, and collective cell behavior across
Superresolution Imaging System Generates Segmented Fossil Images
PRINCETON, N.J., March 8, 2018 — Using an industrial grinder and superresolution camera, geoscientists have created 3D digital images of rock samples that can be viewed from multiple angles. Algorithms allow the computer to segment the images without human bias. Scientists used...
Microscope Provides Precise 3D Imaging of Thick Mammalian Cells
STANFORD, Calif., March 5, 2018 — A new microscope produces 3D nanoscale images of mammalian cells in their entirety. Because the axial positions of the single emitters are encoded in the shape of each single-molecule image rather than in the position or thickness of the light...
NIH Team Improves 3D Imaging Efficiency, Speed and Resolution
WASHINGTON, D.C., Nov. 15, 2017 — Researchers have developed a technique that improves the spatiotemporal resolution and collection efficiency of light-sheet fluorescence microscopy (LSFM), without modifying the underlying microscope. The technique instead uses reflection to improve...
Broad Palette of Fluorescent Dyes May Advance Biological Imaging
ASHBURN, Va., Oct. 19, 2017 — To better illuminate the inner workings of cells, researchers have developed a way to adjust the properties of fluorescent dyes deliberately, resulting in an expanded palette of dyes that are bolder, brighter and more cell-permeable. Their novel...
Silicone Immersion Objectives Answer the Call for Higher Resolution
Sep 21, 2017 — Refractive index mismatch, and resulting spherical aberration, has historically plagued researchers interested in long-term, live-cell imaging at high resolution. The use of silicone oil objectives helps mitigate this mismatch as the refractive...
Subwavelength THz Could Improve Image Resolution, Accelerate Imaging Speed
EXETER, England, Sept. 5, 2017 — A terahertz (THz) imaging technique that is compatible with adaptive and compressive sensing algorithms has been developed and has demonstrated image reconstruction at highly subwavelength dimensions. Using a near-field approach to THz imaging,...
Imaging Array Captures Minute Details From a Distance
HOUSTON, April 25, 2017 — A unique camera that can capture a detailed micron-resolution image from a distance uses a laser and techniques that borrow from holography, microscopy and "Matrix"-style bullet time. Engineers from Rice and Northwestern Universities built the...
Optical Nanoscopy Images DNA Naturally Fluorescing
EVANSTON, Ill., March 3, 2017 — A novel imaging tool that is able to capture images of DNA naturally fluorescing could advance the study of individual biomolecules and help uncover global patterns of gene expression. Existing methods for imaging DNA and other genetic material rely...
Imaging Platform Improves Limited Resolution Abilities of Single-Molecule Microscopes
BOSTON, Feb. 13, 2017 — A new highly versatile and inexpensive microscope imaging platform has been developed that is designed to visualize objects with molecular-scale resolution and unprecedented complexity. Scientists from Wyss Institute at Harvard University have...
Optical Tractor Beam Traps Bacteria
BIELEFELD, Germany, Dec 20, 2016 — Physicists at Bielefeld and Frankfurt Universities are studying blood cells, algae and bacteria by trapping these biological cells with a laser beam. Using this procedure they have obtained superresolution images of the DNA in single bacteria....
Superresolution Microscope Builds 3D Images by Mapping Negative Space
AUSTIN, Texas, Oct. 14, 2016 — Thermal noise imaging, a novel method for making 3D images of biological structures at high resolution and under natural conditions, may offer insight into how cells communicate with one another, helping to further the development of artificial...
Novel Monomer Enhances Resolution in Live-Cell Imaging
BEIJING, Sept. 22, 2016 — A novel protein with a fluorescent probe for imaging live cells could improve live-cell superresolution (SR) imaging. While the use of reversibly switchable fluorescent proteins (RSFPs) reduces illumination intensity and thus enables SR imaging of...
Ultrahigh-Resolution Microscope Images Whole Cells in 3D
WEST LAFAYETTE, Ind., Sept. 12, 2016 — A novel super-resolution nanoscope allows 3D imaging of an entire mammalian cell and its cellular constituents at a resolution that is 20–50 times higher than conventional microscopy, with imaging depth improved ∼10-fold over...
Mirror-Enhanced Microscopy Captures Cell Behaviors
BEIJING, July 5, 2016 — A novel technique for growing cells on miniature mirrors and imaging them using super-resolution microscopy may provide a way to view cell structures at a micron scale. The technique uses light waves to create interference patterns as light passes...
Airy Beam Light-Sheet Microscopy Holds Promise for Life Sciences Imaging
May 24, 2016 — Airy light-sheet microscopy has great potential to help further research and clinical diagnoses through its ability to image larger 3D volumes of tissues and organoids. Developed in the last three years, it is best-suited to the fields of...
Illuminating Microscopy Growth and Demand
May 16, 2016 — A new mini microscope that uses fluorescence imaging is allowing researchers from the Salk Institute for Biological Studies in La Jolla, Calif., to look deeper into the central nervous system. This could lead to novel pain treatments for spinal cord...
Member Exclusive
Lighting Up Microscopes: Advances and Emerging Sources
Apr 27, 2016 — Microscope developers are a resourceful bunch, opting to use the light source available to them at the time to peer at or below the surface of various materials. Even dating back to the 17th century, Galileo used sunlight to produce the very first...
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Eric Betzig Group Takes $25K Prize for Light-Sheet Microscopy Advance
WASHINGTON, D.C., Jan. 13, 2016 — The American Association for the Advancement of Science (AAAS) has awarded its $25,000 Newcomb Cleveland Prize to Nobel laureate Eric Betzig and colleagues for advancing light-sheet microscopy for live-cell imaging. Their approach causes less damage...
LEDs in Biology Research: From Microscopy to Optogenetics
Dec 17, 2015 — Microscopy has long held a crucial place in bioscience research, dating back to the first observations of living cells. Techniques that include the use of LEDs have been developed — and continue to be — to meet new and evolving demands...
Thin-Film Optical Filters for Phase Control Applications
Nov 30, 2015 — Thin-film filters (TFFs) can create virtually any spectral shape imaginable to modify the transmission or reflection of light in optical systems. During design, strong emphasis is often placed on optimizing the amplitude response, although for many...
NKT Photonics Supplies Supercontinuum Lasers to Leica Microsystems
BIRKERØD, Denmark, Nov. 30, 2015 — Leica Microsystems GmbH has signed a 14-month supply contract with NKT Photonics A/S to deliver its SuperK EXTREME supercontinuum lasers to power the Leica TCS SP8 X confocal microscope for bioimaging. The white-light laser enables excitation at any...
Calibration Sharpens Superresolution Microscopes
STANFORD, Calif., Nov. 23, 2015 — Superresolution microscopes can be made even sharper with arrays of nanoscale apertures that compensate for optical aberrations more effectively than previous techniques. The arrays allow for more accurate tracking of individual molecules in 3D,...
Research Innovation Recognized by Edmund Educational Awards
BARRINGTON, N.J., Nov. 11, 2015 — Researchers behind a flow cytometer for seawater, a 3D superresolution microscopy technique and the study of bubbles took top honors in this year's Educational Awards presented by Edmund Optics Inc. The awards recognize undergraduate and graduate...
Dye Endures Repeated STED Irradiation
NAGOYA, Japan, Oct. 27, 2015 — Photostable fluorescent dye for superresolution microscopy could serve as a powerful tool to visualize biological events and structural details in living cells for prolonged periods. Researchers at Nagoya University have developed a new fluorescent...
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