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Building a Room for a Bacterium

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Mask-based lithography directs multiphoton cross-linking of proteins.

Hank Hogan

University of Texas at Austin researchers Bryan J. Kaehr and Jason B. Shear have developed a way to rapidly generate microscale patterns in biomaterials using a technique dubbed mask-directed multiphoton lithography. Among other applications, they have used the method to transfer the outline of a housefly into biomaterials and to fabricate protein-based microchambers to trap and incubate a single moving bacterium. Using mask-directed multiphoton lithography, researchers fabricated the word “avidin” from a solution containing the biotin-binding protein of the same name (top). They washed...Read full article

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