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BioPhotonics - September 2011
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Issue Library
Features
Photoacoustic Microscopy Unlocks Secrets of Optical Absorption
Mainstream optical microscopy technologies cannot sensitively measure the optical absorption that provides essential physiological information such as the concentration and oxygen saturation of hemoglobin. In our research, we have implemented subwavelength-resolution photoacoustic microscopy (SW-PAM) to provide high-optical-absorption contrast by using a water-immersion optical objective...
Intrinsic Fluorescence Lights Up Cellular Components
Multiphoton microscopy is especially useful when intrinsic fluorescence imaging is combined with other label-free imaging modalities, such as second-harmonic generation or coherent anti-Stokes Raman...
Fluorescence Imaging Progressing from Cells to Tissue
Tissues and even whole animals are not as easily captured with fluorescence imaging as are cells, but recent research and technological developments could change that. Fluorescence imaging has become...
Multiplexed Sensing with QD-based FRET
For more than a decade, investigators have explored the potential of quantum dot (QD)-based Förster resonance energy transfer (FRET) for multiplexed diagnostics, noting the unique photophysical...
Photon by Photon
Since the photomultiplier tube (PMT) was invented in the mid-1930s, it has remained the principal detector for experiments involving a small number of photons. However, its low photon detection...
Editorial
Good news for biophotonics
Whether you follow the political or economic stories – or both – affecting life and business (if you have the stomach for it), you know that there hasn’t been a lot of good news lately. And questions abound regarding the impact of recent moves and markets on science and technology research. As the two worlds move toward steadier ground, researchers everywhere continue to push...
BioScan
MicroOCT advances understanding of atherosclerosis
Coronary atherosclerosis could someday be more easily diagnosed and treated, thanks to a new version of the intravascular imaging technology optical coherence tomography that provides a resolution 10...
Semiconductor nanowire laser tech could kill viruses, purify water
A semiconductor nanowire laser technology that can kill viruses, purify drinking water and more has been discovered by scientists at the Bourns College of Engineering at the University of California,...
Cornell dots characterized, ready for human trials
The bright nanoparticles known as Cornell dots could light up cancer cells in PET optical imaging, and the technology, recently approved as an “investigational new drug” by the FDA, is...
GFP helps turn single cell into “living laser”
For the first time, a single living cell has been genetically engineered to produce nanosecond pulses of laser light. The “living laser,” developed by two researchers at the Wellman...
Microscope gains a fourth dimension
Extending the technology of the three-dimensional microscope, scientists have added a dimension that promises sweeping applications in biological research, medicine and the development of new...
Bird’s-eye view used to craft autopilot technology
Once used as wartime messengers, pigeons now have a new calling: acting as informants for navigation technology design. Harvard University research involved training messenger pigeons to fly...
Scientists reach for the stars to find new radiation treatments
Many have looked to the stars for inspiration, but could a new cancer therapy be up there as well? Ohio State University astronomers think so. After studying how different chemical elements...
“Unnatural” amino acids probe mysteries of neural stem cells
Before stem-cell-based regenerative medicine can advance, scientists must understand how stem cells work and what kinds of cells they produce. Salk Institute research recently uncovered a way to...
Reward-seeking behavior regulated with optogenetics
Scientists have used optogenetics to control reward-seeking behaviors such as drug addiction in rodents, demonstrating the roles of specific connections in the brain that control behavior. Through...
Glowing gland could reduce endocrine surgery risk
Parathyroid glands – four small organs the size of grains of rice located at the back of the throat – are very difficult to identify with the naked eye, and they can be damaged during...
New gold nanoparticles serve as biomedical “test bed”
Gold nanoparticles could be used as a “test bed” to explore how the tiny particles behave in biological systems, according to a new report. It also suggests a new model for the...
Forgotten bioluminescent mushroom comes out of hiding
A glow-in-the-dark mushroom not seen since 1840 has been rediscovered in a Brazilian rain forest and reclassified. The bioluminescent fungus was discovered by San Francisco State University...
Ovarian cancer’s first stages imaged
A new model of time-lapse microscopy has been created to provide better visualization of metastatic processes in their early stages. Researchers at Harvard University have created a laboratory...
Measuring macromolecules in 3-D
Three-dimensional plasmon rulers that can measure nano-meter-scale spatial changes in macro-molecular systems could provide scientists with unprecedented details on critical dynamic events in biology...
Lab-on-chip combines laser, electric field
A new technology called hybrid optoelectronic manipulation in microfluidics combines a laser with electric fields and promises a new lab-on-a-chip designed to manipulate DNA, bacteria and viruses for...
Tiny lens-free camera takes pixel-perfect pictures
A microscopic device that fits on the head of a pin, contains no lenses or moving parts, and costs just pennies to make could someday revolutionize surgery, robotics and other science applications. ...
RapidScan
OCT researchers garner grants for glaucoma detection
OCT could become even more useful in glaucoma detection, diagnosis and research, thanks to new grants from the American Health Assistance Foundation, which funds research on age-related diseases. The...
Biomagnetics Diagnostics Corp.
Biomagnetics Diagnostics Corp., based in Orangevale, Calif., has accepted delivery of a biosensor that is proposed for use in diagnosing cholera, tuberculosis and malaria. The sensor could be in...
Navitar Life Sciences Inc.
Navitar Life Sciences Inc., an affiliated entity of optics manufacturer Navitar Inc. of Rochester, N.Y., has agreed to acquire the assets of 9762%%Modulation Optics, including its Hoffman Modulation...
OSA Foundation (OSAF)
The OSA Foundation (OSAF) in Washington has announced a fiscal sponsorship agreement with the International Commission for Optics (ICO) that will allow charitable donations made to OSAF to be...
Biolase Technology Inc.
Dental laser manufacturer Biolase Technology Inc. of Irvine, Calif., has received two more patents from the US Patent and Trademark Office for its laser technologies that treat various eye...
Carl Zeiss
Carl Zeiss and Digital Surf have signed an agreement that enables Zeiss to provide Digital Surf’s ConfoMap surface imaging and analysis software for use with its confocal microscopes. The...
Daylight Solutions Inc.
Daylight Solutions Inc. of San Diego has closed a $15 million Series C equity financing round with Northrop Grumman Corp., the lead investor, and several of the company’s existing investors....
Halma
Safety, health and sensor technology group Halma of Amersham, UK, has acquired Avo Photonics Inc. from Blaine Hobson, Whitecap Partners, and other shareholders and employees for an initial cash...
Lumex
Lumex of Palatine, Ill., and element14 have formed a strategic partnership that allows electronic design engineers in the Asia-Pacific region to acquire more than 8000 Lumex optoelectronic components...
Mad City Labs Inc.
Mad City Labs Inc. of Madison, Wis., a manufacturer of flexure-based nanopositioning systems, has appointed 4286%%Elliot Scientific Ltd. of Harpenden, UK, as its exclusive distributor within the UK...
Michelson Diagnostics
Medical device company Michelson Diagnostics plans to expand its new US subsidiary, Michelson Diagnostics Inc., to increase the availability of its skin cancer imaging products. The company has...
Sporian Microsystems
Sporian Microsystems, a developer of sensors and sensor systems based in Lafayette, Colo., has shipped first article units for a new in-line biological sensor based on its patented technology. The...
Tyndall National Institute UCC
Tyndall National Institute UCC has launched InfiniLED Ltd., a high-tech spinout that will commercialize a new generation of LED technology that extends the battery life of portable devices such as...
University of Warwick
In the UK, the University of Warwick’s physics department has been awarded a five-year grant of £1.7 million (about $2.7 million) for its initiative “Creating Silicon Based...
Zecotek Photonics Inc.
Zecotek Photonics Inc. has been granted Patent No. 7,956,331 B2 by the US Patent and Trademark Office for a depth of interaction technology that was developed to provide improvements in the precision...
Zygo Corp.
The Optical Systems Div. of Zygo Corp. has been awarded a $3 million continuation order from Commissariat à l’énergie atomique for its meter class laser fusion amplifiers. The...
Postscripts
Seeing the fluorescence for the trees
The subtle fluorescence that plants emit during photosynthesis – invisible to the naked eye – could provide a rapid picture of how healthy the world’s land vegetation really is. Using satellites – instead of the ground-based or airborne instruments commonly used to measure the fluorescence – scientists from NASA Goddard Space Flight Center in Greenbelt, Md.,...
Products
CCD USB 2.0 Camera
Lumenera Corp. has released the Infinity2-5, a digital CCD USB 2.0 camera engineered for qualitative image archiving in life sciences, clinical and materials science applications that require high resolution and sensitivity. The 5-megapixel camera employs the Sony Super HAD ICX655 2/3-in. sensor featuring 3.45-μm square pixels. An 8-bit output is available for capturing fast video of live...
Teledyne Lumenera
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Laser Scanning Microscopes
The VK-X series 3-D laser scanning microscopes from Keyence Corp. of America combine the capabilities of scanning electron microscopes and noncontact roughness gauges with the simplicity of an...
Keyence Corp.
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Microscopy Software
Bitplane, part of Andor Technology plc, has released its Imaris 7.3 image processing, analysis and visualization software. New capabilities include novel segmentation functions in ImarisCell,...
Bitplane USA
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Raman Analyzers
BaySpec Inc. has introduced its next-generation FirstGuard dispersive multiwavelength handheld Raman analyzers. Features include excitation wavelengths of 532, 785 and 1064 nm; a high-power ~490-mW...
BaySpec Inc.
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Bandpass Filters
Infrared OD 4 bandpass filters that provide the high transmission and deep rejection necessary to isolate narrow spectral regions have been unveiled by Edmund Optics. They are durable, and their...
Edmund Optics Inc.
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Code Reader
Sick Inc. has introduced the Lector620, an image-based reader for 1- and 2-D codes that is suitable for track and traceability applications. It offers intelligent setup and intuitive operation,...
SICK Inc.
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Achromatic Beam Shaping Optics
Launched by AdlOptica GmbH, the πShaper 6_6 series achromatic refractive field-mapping beam shapers includes the πShaper 6_6_NUV, the 6_6_VIS and the 6_6_NIR. Optimized to operate,...
AdlOptica GmbH
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Microscope Stage
Prior Scientific Inc. has unveiled the H117P2NN flattop motorized stage for the Nikon Ti series inverted microscopes. Although suitable for use in high-precision biomedical and materials science...
Prior Scientific Inc.
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End-Face Interferometer
Arden Photonics Ltd. has launched the VFI-1200 optical fiber end-face interferometer, based on the company’s VF-20 Trio. The interferometric inspection system is designed for checking the...
Arden Photonics Ltd.
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Ultrafast Intensified CCD
Andor Technology plc has added the DH320T model to its iStar range of scientific-grade intensified CCDs for spectroscopy applications. It offers high sensitivity, —40 °C thermoelectric...
Andor Technology
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552-nm OPSLs
Coherent Inc. has announced a family of commercial, all-solid-state optically pumped semiconductor lasers (OPSLs) with output at 552 nm. The Sapphire 552 LP lasers offer continuous-wave output of 50,...
Coherent Inc.
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Streak Cameras
For ultraviolet to near-infrared measurements of extremely fast light phenomena, Hamamatsu Photonics has introduced the C10910 streak cameras. The series simultaneously delivers intensity vs. time...
Hamamatsu Corporation
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Megahertz OPA
The Europa optical parametric amplifier (OPA) from Elliot Scientific Ltd. is directly pumped by submicrojoule pulses provided by the FemtoSource high-energy oscillators such as the XL 500 and XL 650....
Elliot Scientific Ltd.
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Vacuum Stages
Steinmeyer Inc. offers a range of precision stages suitable for ultrahigh-vacuum applications. The model MT105-LM-HV is one example. A compact two-axis (X-Z) version has a travel range choice of 30...
Steinmeyer Inc.
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Single-Photon-Counting Modules
The COUNTblue series single-photon-counting modules manufactured by Laser Components GmbH achieve a quantum efficiency of 60% in the blue spectral range and 70% in the yellow and green wavelengths....
Laser Components Germany GmbH
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Bioanalysis Lighting
Lumencor Inc. has launched Core, a bioanalysis illumination and imaging system that offers equipment manufacturers a streamlined optical block based on the company’s solid-state excitation...
Lumencor Inc.
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Cell Imaging System
The cell imaging and analysis instrument Cell Metric from Solentim Ltd. is engineered to provide a high-throughput work flow solution to screen for colonies from single-cell cloning experiments. It...
Solentim Ltd.
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Microfabrication Workstation
Newport Corp. has introduced the Laser μFAB, a tabletop laser microfabrication workstation for research applications. It is designed for use in additive and subtractive processes, including 3-D...
MKS/Newport
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Deep Tissue Imaging
For deep tissue imaging, Spectra-Physics, a Newport Corp. brand, has released the InSight DeepSee ultrafast laser system. Based on proprietary technology, the turnkey device delivers nearly double...
MKS/Spectra-Physics
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Slide Scanner
The SCN400 F from Leica Microsystems Inc. is an all-in-one digital pathology slide scanner for high-end bright-field and fluorescence applications. It combines good bright-field scanning and...
Leica Microsystems Inc.
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Camera Software
Toshiba Imaging Systems Div. has announced a customized software interface for its IK-TF7 three-chip color cameras that enhances fluorescence imaging in living retinal tissue. The release of...
CANON MEDICAL COMPONENTS U.S.A., Video Sensing Devices
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Glass-Bottom Microplates
Manufactured to be extremely flat (±15 μm across the base), Krystal glass-bottom microplates from Porvair Sciences Ltd. are suitable for use in whole-plate CCD imaging and laser detection...
Porvair Sciences Ltd.
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Spectrofluorometers
Building upon the capabilities of the FP-6000 series, the FP-8000 series spectrofluorometers from Jasco Inc. provide additional features and innovations. They incorporate high sensitivity, fast...
JASCO Inc.
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