Request InfoApplied Scientific Instrumentation Inc.ASI has developed a new form of light sheet microscopy with our collaborators in the scientific community. The diSPIM system from ASI is an extremely cell friendly system for imaging live specimens as it only illuminates the region of the specimen that is being viewed, reducing phototoxicity and reducing photobleaching ~7-10 fold. Unlike other SPIM systems, the diSPIM allows the use of conventional mounting and glass coverslips.See full productRelated content from Photonics MediaPRODUCTSPromoted Content November 2023 IssueAutomated Fluorescence, SimplifiedCoolLED’s Amora Series for custom microscopy illumination is based on an established portfolio of off-the-shelf products, adapted to offer unparalleled customization opportunities. This...Promoted Content September 2022 IssueAward-winning Microscopy IlluminationCoolLED, a global expert in LED microscopy illumination, is helping scientists reach the full potential of their widefield fluorescence microscopy and optogenetics experiments with the popular pE-300...Promoted Content May 2023 IssuePowerful LED Illumination for Every ApplicationCoolLED, a global expert in LED microscopy illumination, is helping scientists reach the full potential of their widefield fluorescence microscopy and optogenetics experiments with its broad range of...Promoted Content October 2023 IssueLED Technology for OEM ApplicationsCoolLED’s Amora Series for custom microscopy illumination is based on an established portfolio of off-the-shelf products, adapted to offer unparalleled customization opportunities. This...ARTICLESBioPhotonics Nov/Dec 2023 IssuePhotoacoustic Microscopy Method Delivers Higher SensitivityA multispectral, super-low-dose photoacoustic microscopy (SLD-PAM) system developed by City University of Hong Kong (CUHK) achieves significantly higher sensitivity than traditional optical...BioPhotonics Jul/Aug 2023 IssueCentury-Old Effect Applied for Study of Embryonic DevelopmentResearchers have applied line-scanning Brillouin microscopy (LSBM), a microscopy technique based on Brillouin scattering, to visualize the mechanical properties of living cells over space and time,...BioPhotonics Sep/Oct 2023 IssueDNA-Barcoded Fluorescence Imaging Illuminates Core Cell ComponentsSince many core components of cells — like DNA, RNA, proteins, and lipids — are just a few nanometers in size and substantially smaller than the resolution limit of traditional light...Photonics.com 10/14/2022Leonardo DRS Secures Army Contract; ZEISS Microscopy Strikes Contract: Week in Brief: 10/14/2022ARLINGTON, Va. — Leonardo DRS received a contract to produce its next-generation thermal weapon sights for the U.S. Army. The firm fixed-price contract from the U.S. Army Contracting Command is...PHOTONICS HANDBOOK ARTICLESPhotonics HandbookSuperresolution Microscopy: An Imaging RevolutionSuperresolution optical microscopy, for which the Nobel Prize was awarded to Eric Betzig, Stefan Hell, and William Moerner in 2014, has been one of the most momentous developments in the life...Photonics HandbookNSOM: Discovering New WorldsNSOM is suitable for studies on the mesoscopic scale (several tens to hundreds of molecular dimensions). It has become an important tool in research and applications of semiconductors, organic layers...Photonics HandbookMeasuring Surface Roughness: The Benefits of Laser Confocal MicroscopyWhen evaluating the surface of a component, surface roughness can be assessed by eye or by rubbing it with a fingertip. Common expressions include “shiny,” “lusterless and...Photonics HandbookFluorescence Lifetime Imaging: Choosing the Best ApproachThe term fluorescence is often applied as a synonym for photoluminescence, although luminescence actually covers fluorescence and phosphorescence. Both of these terms describe the process of...WHITEPAPERSPhotonics.com 9/27/2023Raman SpectroscopyTo achieve accurate and precise Raman measurements, optical filters play a crucial role in enhancing signal-to-noise ratio, and reducing background interference. This white paper explores the...Photonics.com 1/10/2024Single-Objective Light SheetAn overview of the Single-Objective Light Sheet.Photonics.com 10/26/2022Methods of Imaging with Photoelastic ModulatorsThis paper highlights a range of options to utilize Photoelastic Modulators (PEMs) with imaging systems to generate full field polarimetric measurements. Due to the resonant nature of the...Photonics.com 9/12/2022Ingenuity + Instrumentation: Creating a Novel 4D Microscopy MethodTracking particles at the micro or nanoscale is inherently difficult due to the complexity of the systems studied, as well as the technical challenges: a blend of instrument design, photonics,...WEBINARSPhotonics.com 8/4/2020An Oblique Plane Light-Sheet Microscope with 200-nm-Scale ResolutionLight-sheet fluorescence microscopy (LSFM) has generated significant interest in the biological community. Not only does it deliver light to only the in-focus portion of a specimen, decreasing the...Photonics.com 10/25/2018Shareable Advanced Light-Sheet Microscopy Using FlamingoThis webinar will discuss a new model for advanced microscopy, based on shareable, modular instruments. This model, called Flamingo, is designed to bridge the gap between biology and technology....Photonics.com 10/25/2022Selecting the Right Optics for Ultrafast MicroscopyUltrafast lasers are being increasingly used in life science imaging techniques such as multiphoton microscopy. However, the short pulse durations and high peak powers of ultrafast lasers make...Photonics.com 1/22/2021Using LEDs to Enhance Image Quality and Cell ViabilitySince their debut over a decade ago, LEDs have had an ever increasing impact on the world of fluorescence microscopy. To appreciate this growth in popularity, Alex Gramann addresses many of the...PHOTONICS DICTIONARY+ TERMSPhotonics Dictionarylight sheet fluorescence microscopyAlso known as single plane illumination microscopy (SPIM), this process was designed for imaging of sensitive samples and fast biological processes in vivo. In this method, a light sheet illuminates...Photonics Dictionarystructured illumination microscopyStructured illumination microscopy (SIM) is an advanced optical imaging technique used in microscopy to enhance the resolution of images beyond the diffraction limit imposed by traditional light...Photonics Dictionarysingle molecule localization microscopySingle molecule localization microscopy (SMLM) is a group of super-resolution microscopy techniques that surpass the diffraction limit of traditional optical microscopes, allowing for the...Photonics DictionarySTED microscopySTED microscopy, or stimulated emission depletion microscopy, is a superresolution imaging technique in fluorescence microscopy that surpasses the diffraction limit, enabling the visualization of...VIDEOSPhotonics.com 11/20/2023Andor's Life Science Research SolutionsAt Andor, it matters to us that the products we develop make a real difference to our customers and contribute significantly to their research across Immunology, Microbiology, Neuroscience, Cells &...Photonics.com 11/20/2023New ZL41 Cell & Sona sCMOS - Easy, Flexible, Cost-Effective Super Resolution Microscopy - Andor TechnologyEasy and Cost-Effective Super-Resolution to ~100 nm. Andor has introduced two new highly innovative sCMOS cameras, both delivering easy and cost-effective access to super-resolution capabilities and...Photonics.com 5/2/2022Applied Scientific InstrumentationEstablished in 1990, Applied Scientific Instrumentation is a reknown American company committed to the advancement of science. ASI products have been thoroughly tested and evaluated in numerous labs...Photonics.com 11/20/2023New Dragonfly 600 Confocal Microscope System - Andor TechnologyThe Dragonfly 600 confocal microscope system delivers outstanding multi-dimensional images from subcellular (nm) to whole organism (cm), while significantly boosting productivity. Its unrivalled...PHOTONICS BUYERS' GUIDE CATEGORIESPhase Contrast MicroscopesScanning Electron Microscopes (SEM)A scanning electron microscope is an electron microscope that uses a beam of electrons -- accelerated to high energy and focused on the sample -- to scan the sample surface, ejecting secondary...Scanning Probe MicroscopesBioluminescence MicroscopesCOMPANIESPhotonics Buyers' GuideApplied Scientific Instrumentation Inc.Applied Scientific Instrumentation, Inc. (ASI) is a company committed to the advancement of science. Our engineers and technicians have years of experience in aiding researchers with their technical...Photonics Buyers' GuideOptikos CorporationThe Optical Engineering Experts® Optikos designs and manufactures metrology products for measuring and assuring optical image quality; and provides optical engineering design, development,...Photonics Buyers' GuideAndor TechnologyAndor Technology Ltd is a global developer and manufacturer of high-performance scientific cameras, microscopy systems and spectrographs for academic, government, and industrial applications. Founded...Photonics Buyers' GuideOZ Optics LimitedEstablished in 1985, OZ Optics is a leading worldwide supplier of fiber optic components, test equipment and sensors. OZ Optics manufactures its products in three locations, Ottawa (Canada),...