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Howard Hughes Medical Institute News
Member Exclusive
Better Biomedicine via 3D Imaging
Oct 23, 2019 — Advancements in biomedical 3D imaging promise to improve research findings and clinical outcomes, thereby producing widespread benefits. In research, a combination of techniques will enable high-speed visual 3D imaging effectively below the diffraction limit, allowing scientists to better track what goes on in the brain or to examine other tissues and organs. The results of these advancements could be discoveries about how the brain works and how diseases progress. Fruit fly
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Bright, Photostable Dye Developed for In Vivo Voltage Imaging
ASHBURN, Va., Aug. 12, 2019 — A “misfit” fluorescent dye, developed to round out a spectrum of dyes, is becoming a cornerstone of a new brain imaging tool developed at Howard Hughes Medical Institute’s Janelia Research Campus. The tool, which is named Voltron,...
Two-Photon Microscope Captures Brain Activity at Record Speed
ASHBURN, Va., Aug. 9, 2019 — A new two-photon microscope from scientists at Howard Hughes Medical Institute’s Janelia Research Campus records footage of brain activity 15 times faster than once believed possible, the team said, revealing voltage changes and...
Microscopy Techniques Combine for Nanoscale Brain-Wide Imaging
ASHBURN, Va., and CAMBRIDGE, Mass., Jan. 21, 2019 — Scientists from the Eric Betzig lab at Howard Hughes Medical Institute’s Janelia Campus and the Ed Boyden Lab at Massachusetts Institute of Technology (MIT) collaborated to develop an imaging technique, ExLLSM, that combines expansion microscopy...
Microscope Images Mouse Embryo Development at the Cellular Level
ASHBURN, Va., Oct. 15, 2018 — Researchers at Howard Hughes Medical Institute’s Janelia Research Campus developed a new microscope using adaptive light-sheet microscopy techniques to capture mouse development at the single-cell level. The team is making the microscope and...
Illuminating Microscopy Growth and Demand
May 16, 2016 — A new mini microscope that uses fluorescence imaging is allowing researchers from the Salk Institute for Biological Studies in La Jolla, Calif., to look deeper into the central nervous system. This could lead to novel pain treatments for spinal cord...
Optogenetics Pioneers Ed Boyden, Karl Deisseroth, Gero Miesenböck Garner International Research Prizes
SAN FRANCISCO and MAINZ, Germany, Nov. 10, 2015 — Three optogenetics researchers have been recognized with international awards for their pioneering work on controlling cells with light. Ed Boyden, of the Massachusetts Institute of Technology, and Karl Deisseroth, of Stanford University and the...
Light-Sheet Microscope Pushes Resolution Limits
ASHBURN, Va., Oct. 26, 2015 — With resolution seven times greater than conventional light-sheet microscopes, a new device can capture cell-level 3D images across entire small organisms. Developed at the Howard Hughes Medical Institute's Janelia Research Campus, the microscope...
Superresolution Microscopy Pioneers Win Nobel Prize in Chemistry
STOCKHOLM, Sweden, Oct. 8, 2014 — Circumventing the diffraction limit to achieve nanoscale microscope images has earned Eric Betzig, Stefan W. Hell and W.E. Moerner the 2014 Nobel Prize in Chemistry.
Zeiss, Janelia to Commercialize Fluorescence Technique
ASHBURN, Va., Sept. 10, 2104 — The Howard Hughes Medical Institute’s Janelia Research Campus has teamed up with Carl Zeiss Microscopy GmbH to commercialize Bessel beam plane illumination microscopy, also called lattice light sheet microscopy.
Adaptive Optics Enhances Subcellular Imaging
ASHBURN, Va., April 14, 2014 — A new adaptive optics technique is being used by biologists seeking sharper microscope images.
Trends in Imaging
Jan 16, 2014 — Advanced data mining, 3-D video imaging techniques and image fusion are bringing to fruition superaccurate real-time diagnostics, brain mapping and futuristic driverless cars. Developments in photonics have changed the landscape of imaging in...
Optics Community Hails Obama’s Brain Mapping Initiative
WASHINGTON, April 4, 2013 — Neuroscientists and bioengineers — including the inventor of a neuronal control technique involving gene therapy and lasers — voiced support this week for the BRAIN Initiative, unveiled by President Barack Obama at a White House press conference on...
Genetic tags illuminate life
SAN DIEGO – A new type of genetic tag made by modifying a plant protein has the potential to illuminate life in never-before-seen detail. Scientists from the University of California, San Diego (UCSD), School of Medicine have re-engineered a...
Sheets of Light Image Live Cells
ASHBURN, Va., March 7, 2011 — Using an exquisitely thin sheet of light, a newly developed microscope reveals the 3-D shapes of cellular landmarks in unprecedented detail. The technique images live cells at high speed so that researchers can create dazzling movies that make...
Improving Microscopy by Using a Guide Star
WASHINGTON, Feb. 17, 2011 — A corrective strategy used by astronomers to sharpen images of celestial bodies can now help scientists see with more depth and clarity into the living brain of a mouse. Eric Betzig, a group leader at the Howard Hughes Medical Institute’s...
FRET Tracks Single Enzyme
CHAMPAIGN, Ill., Sept. 20, 2010 — Thanks to a single-molecule imaging technique developed by a University of Illinois professor, researchers have revealed the mechanisms of an important DNA-regulating enzyme. Helicase enzymes are best known for “unzipping” DNA for...
Filming Early Animal Development
HEIDELBERG, Germany, July 12, 2010 — The transformation of a single cell into a complete animal is amazing and complicated. Cells must divide and migrate through the ever-changing embryo, shaping themselves into specialized organs. And it happens at a blistering pace: a zebra fish...
Cells Respond to Laser Light
SAN FRANCISCO, Sept. 15, 2009 – For the first time, researchers have imported a light-controlled “on-off switch” from plants into a mammalian cell to instantly control a variety of cell functions by creating a hybrid protein that causes mouse cells to move in response to laser...
Lasers Induce Brain Waves
CAMBRIDGE, Mass., April 27, 2009 – Researchers at MIT used a new technology called optogenetics, which combines genetic engineering with light to manipulate the activity of individual nerve cells, to induce gamma waves in mouse brains. The resulting information about neuron function...
FRET Technique Developed to Observe DNA-Repairing Protein
CHAMPAIGN, Ill., Aug. 15, 2006 -- Researchers have observed the life cycle of RecA, a protein that plays a major role in repairing damaged DNA, by using a highly sensitive, single-molecule fluorescence resonance energy transfer (FRET) technique they developed . A better...
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April 2024
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