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BioPhotonics: November 2006

BioPhotonics
 November 2006


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FEATURES
Endoscopic Confocal Microscopy Moves into the Clinic Endoscopy is a minimally invasive procedure used to screen patients and to investigate a wide variety of suspected health issues. It often involves a biopsy for subsequent laboratory analysis with various methods that include visual microscopy. However, the approach often fails to spot precancerous problems and small cancerous growths. Doctors would like to spot precancerous tissue and small...
Optical Filters for Multiphoton Microscopy Multiphoton fluorescence microscopy is similar to conventional fluorescence microscopy in that it images fluorescence from molecules that tag a target of interest in a cell. However, in a two-photon...
Flow Cytometry Moves Ahead When it comes to counting, examining and sorting cells in a moving fluid stream, researchers are not content to go with the flow. They are constantly looking for ways to improve the flow cytometers...
RAPIDSCAN
Laser sheds light on Parkinson’s disease Worldwide, millions of people suffer from Parkinson’s disease, and they gradually lose control of their movements. For example, their hands may shake uncontrollably, or their muscles may...
A fossil record of cell division Using thin section petrology, scanning electron microscopy, transmission electron microscopy and x-ray CT, researchers have uncovered fossilized evidence of cell division. The cells that they found...
Cell-based assays become three-dimensional Cell-based assays can enable pharmaceutical manufacturers to determine the efficacy and toxicity of a drug. In these assays, cells containing a fluorescent reporter molecule grow in a single...
Bacterial swimming efficiency measured in optical trap Escherichia coli swim from site to site in search of food, using several helical flagella (typically a few microns in length and 20 nm in diameter) for propulsion. Although there is significant data...
A view of what will come Diseases such as glaucoma and retinitis pigmentosa progressively destroy eye tissue, causing patients to lose peripheral vision. As a result, they have tunnel vision. Patients who have tunnel vision...
UV radiation triggers drug antidote Drug-inhibiting antidotes are important for preventing unwanted side effects caused by overdosing, particularly for drugs that inhibit blood clotting, where an overdose could lead to life-threatening...
Near-IR system detects inadequate blood flow Hypoperfusion, or inadequate blood flow to tissues and organs, is life-threatening and a leading cause of death in a critically ill person. Research presented in September at the American Association...
Mammal’s tiny brain charted It took three years of toil, millions of images and a considerable fortune for researchers at the Allen Institute for Brain Science in Seattle to complete a project so vast some doubted its chances...
JPK Instruments AG JPK Instruments AG of Berlin, an atomic force microscope supplier for life sciences and soft matter applications, has acquired light power instruments GmbH, also of Berlin, a company focused on the...
Optopod Ltd. Optopod Ltd., a spinoff company of the University of Kent in the UK, has invented a method, based on optical coherence tomography, to image superficial tissue without damaging it. The technology is...
Nikon UK Ltd. Nikon UK Ltd. at Kingston upon Thames has unveiled a demonstration imaging suite that houses confocal microscopes, total internal reflection fluorescence microscopes and digital imaging equipment for...
SensL SensL, a provider of low-light photon detection sensors and modules, has announced a global expansion of its distributor network to keep pace with demand for solid-state photon detection products....
Cambridge Research & Instrumentation Inc. (CRi) Cambridge Research & Instrumentation Inc. (CRi) of Woburn, Mass., and Invitrogen Corp. of Carlsbad, Calif., have agreed to jointly promote CRi’s Maestro in vivo fluorescence imaging system...
Applied Imaging Corp. Applied Imaging Corp. of San Jose, Calif., has announced that it will be acquired by Genetix Group, the New Milton, UK-based cell biology, proteomics and genomics health technology group. The cash...
BD (Becton, Dickinson and Co.) BD (Becton, Dickinson and Co.) of Franklin Lakes, N.J., has signed an agreement to acquire the 93.5% of the outstanding shares of TriPath Imaging Inc. of Burlington, N.C., that it does not already...
SpectRx Inc. SpectRx Inc. of Norcross, Ga., has received a fifth grant worth $690,000 from the National Cancer Institute (NCI) in Bethesda, Md. The company has been awarded a total of $3.2 million in NCI funding...
Palomar Medical Technologies Inc. Palomar Medical Technologies Inc. of Burlington, Mass., has announced that it will move forward to the next phase in the development of a light-based hair removal device for women to use at home. The...
Gamma Medica-Ideas Gamma Medica-Ideas has been awarded a $100,000 grant to develop a SPECT/MRI small-animal imaging system. The grant is part of an $850,000 fast-track award from the National Institutes of...
Johns Hopkins University Applied Physics Laboratory Bone health analysis software developed by researchers at Johns Hopkins University Applied Physics Laboratory in Laurel, Md., has received FDA 510K clearance that will allow it to be incorporated...
Affymetrix Inc. Affymetrix Inc. of Santa Clara, Calif., and Partners HealthCare of Boston, Mass., have entered into a three-year translational research collaboration to develop microarray-based diagnostics for...
The CAO Group The CAO Group, manufacturers of high-brightness LEDs, displays, and medical, dental and forensic devices, has relocated to a newly built 60,000-sq-ft office and manufacturing facility on 20 acres in...
Dendritic Nanotechnologies Dendritic Nanotechnologies of Mount Pleasant, Mich., known for its special class of nanostructures called dendrimers, has been acquired by the Melbourne, Australia-based nano-biotech company...
AS WE GO TO PRESS
MRI successfully performed via Internet Software that potentially allows an off-site technologist to perform complex MRI procedures over the Internet has been developed by a team of researchers in California, in collaboration with Siemens...
3-D monitor helps test children’s depth perception Stereovision in children is typically tested by random-dot stereogram, which reveals no information if viewed with only one eye. However, tests for children who cannot yet speak require special...
BREAKTHROUGHMEDIA
Fluorescence filter sets A multimedia catalog titled “Precision Optical Filters for Fluorescence Microscopy” has been released by Omega Optical Inc. on compact disc. It introduces the QuantaMax line of stable,...
Nanoscale devices The research, technology and applications driving the growth of nanoelectronics are considered in Nanoelectronics Principles and Devices. The 438-page book brings together the fields of solid-state...
Optics resource The “2006 Optics and Optical Instruments Catalog” from Edmund Optics details more than 8000 products, including new items for UV and biophotonics applications. UV offerings range from...
Glucose monitoring Part of the “Topics in Fluorescence Spectroscopy” series, the 462-page book Glucose Sensing focuses on noninvasive and continuous approaches to physiological glucose monitoring. Written...
FTIR spectrometer Thermo Electron Corp. has launched an interactive online tool that enables scientists to build a Nicolet 6700 Fourier transform infrared (FTIR) spectrometer to their specific application requirements...
Microscope for FTIR Jasco Inc. has released a downloadable three-page document that describes its Irtronμ sample compartment microscopy system, which is compatible with the company’s FT/IR-4000 and -6000 series...
Neuroscience techniques Investigative techniques to study human cognition are examined in Methods inMind. Part of the “Cognitive Neuroscience” series, the illustrated 376-page volume emphasizes how increasingly...
OCT resource The first section of the 625-page work Optical Coherence Tomography: Principles and Applications is for nonphysical scientists, presenting the basic physics and mathematics used in this...
Precision optics A six-panel brochure from Meller Optics Inc. provides an overview of the company’s products and capabilities, which range from custom OEM sapphire optics to off-the-shelf CO2 laser varieties....
LC-MS resource The third edition of Liquid Chromatograpy – Mass Spectrometry discusses how the technique works and how to interpret results, while covering its use for quantitative bioanalysis and...
POSTSCRIPTS
Top images, transforming technologies Winning images in the 2006 Science and Engineering Visualization Challenge take viewers into unfamiliar territory through innovative technological approaches. Now in its fourth year, the contest is jointly sponsored by the National Science Foundation in Arlington, Va., and the journal Science, which is published by the Washington-based American Association for the Advancement of Science. ...
PRODUCTS
Conduction-cooled laser Cube 445, a conduction-cooled laser from Coherent Inc., delivers 40 mW at 445 nm. Designed to replace HeCd gas lasers, the all-semiconductor technology improves reliability, noise, lifetime and beam...
Coherent Inc.
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Quantitative imaging The Lumazone video system from Roper Bioscience is offered in various models for quantitative measurement of chemiluminescence and fluorescence emitted by samples, including whole animals and plants....
Roper Bioscience
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Live-cell imaging Designed to enable users with minimal experience to perform live-cell imaging, the BioStation IM produced by Nikon Instruments Inc. combines an inverted microscope with a vibration-damping chassis...
Nikon Instruments Inc.
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Clinical microscope Olympus Life and Material Science Europa GmbH has released the BX45, part of the BX2 family of clinical microscopes. So that routine microscopists do not have to tilt their heads, the microscope has...
Olympus Europa SE & Co. KG
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Small spectrometer Ocean Optics Inc.’s Red Tide spectrometer has a footprint of 89.1 x 63.3 mm, spectral response from 350 to 1000 nm, an order-sorting filter for eliminating second-order effects, and integration...
Ocean Optics - Part of Ocean Insight
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Video system The Fastcam MH-4 digital video system from Photron Inc. can capture images at 10,000 fps with partial resolution or at 2000 fps with complete 512 x 512 resolution. It comes with four attachable...
Photron USA Inc.
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Laser modules The IQ4X laser diode module from Power Technology Inc. can enable an OEM to retrofit its distributed feedback or fiber-coupled laser diodes for fluorescence measurements, spectroscopy, interferometry...
Power Technology Inc.
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OEM upgrade World Star Technologies Inc. has developed CW, 660-nm, 100-mW red laser diode modules that are designed to enable OEMs to upgrade their systems. They exhibit <1% stability, <0.5-mrad beam...
World Star Technologies
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LED ringlight A high-intensity RGB LED ringlight that produces single red illumination of 592 nm, single green illumination of 520 to 535 nm and blue illumination of 464 to 475 nm has been released by klughammer...
Klughammer GmbH
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Color sensor kit Avago Technologies Ltd. has released an easy-to-use plug-and-play development kit that enables users to evaluate the company’s red, green and blue color sensor products. Suitable for detecting...
Broadcom Inc.
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Nanoalignment stage For nanomanipulation and microsurgery, PI (Physik Instrumente) LP has unveiled the F-206.S HexAlign Hexapod, six-axis nanoalignment stage that features 0.033-μm resolution, 6-D motion, 0.3-μm...
PI (Physik Instrumente) LP, Motion Control, Air Bearings, Piezo Mechanics
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Hyperspectral imager The imaging Bragg tunable filter from Photon etc. inc. is a family of hyperspectral imaging sensors that can acquire monochromatic images at any wavelength in the ultraviolet, visible and...
Photon etc.
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Piezo stage Designed for deconvolution and 3-D imaging, the NanoScanZ piezo stage system from Prior Scientific Inc. features a subangstrom resolution piezo-resistive sensor and 1-nm repeatability. The company...
Prior Scientific Inc.
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Mass spectrometer The ultraflex III smartbeam Maldi-Tof/Tof mass spectrometer from Bruker Daltonics Inc. is suitable for molecular imaging applications. The system’s laser has been improved with...
Bruker Daltonics Inc.
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Optical tables Kinetic Systems Inc. has announced five basic performance levels for its vibration-damping optical tables, each customizable for a specific application. The tables provide flat, stiff and highly...
Kinetic Systems Inc.
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Volt sequencer Designed to supply and manipulate high voltage in MEMS and microfluidics experiments, the HVS448 6000 volt sequencer has been released by LabSmith Inc. It supplies up to 6000 V and can switch channel...
LabSmith Inc.
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Curable adhesives LuminDynamics has released the LD-Ultrabond family of UV-curable adhesives. Upon exposure to ultraviolet light, the adhesives cure to form bonds to a wide variety of substrates. Applications include...
LuminDynamics
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Illumination system Volpi USA has introduced an 18-mm ILP LED coaxial illumination system. This compact version of the company’s CIS product provides stable and homogeneous light output over an 18 x 18-mm area...
Volpi USA
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Fluorescence filters Semrock Inc. has developed BrightLine Clinical hard-coated fluorescence filters that are designed to perform well yet be economical for clinical laboratories. Available filter sets include those for...
IDEX Health & Science - Semrock Optical Filters
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TEM camera Olympus Soft Imaging Systems Corp. is offering the Veleta, a side-mounted TEM camera with a Peltier-cooled CCD chip that has a resolution of 2000 x 2000 pixels and a dynamic range of 14 bits. It uses...
Olympus Soft Imaging Solutions Corp.
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IR neural stimulator Aculight Corp. has introduced the Renoir R-1850, a fiber-coupled laser for infrared neural stimulation. The result of a joint development effort with Vanderbilt University, the device offers...
Lockheed Martin Laser and Sensor Systems
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VIS/NIR spectrometers The portable LabSpec 5000 and 5100 series postdispersive spectrometers, offering 10-nm and 6-nm NIR resolution, respectively, are available from Analytical Spectral Devices Inc. They feature Ethernet...
ASD Inc.
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Protein interaction The ProteOn XPR36 protein interaction array system from Bio-Rad Laboratories Inc. is a surface plasmon resonance imaging optical biosensor. With a 6 x 6 array, it can monitor up to 36 interactions in...
Bio-Rad Laboratories Inc., Informatics Div.
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Frame grabber The Model 314 mpeg-1/2/4 and mjpeg frame grabber captures full-frame (720 x 480) video at 30 fps. Available from Sensoray Co. Inc., it provides uncompressed video for previewing through the PC/104+...
Sensoray Co. Inc.
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Laser controller Cobolt AB has announced a new controller for its Calypso lasers, which are suitable for use in flow cytometry, confocal microscopy and sequencing. The unit is specifically designed for OEM...
Cobolt AB
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Nanopositioning system Available from the DTI-NanoTech division of Discovery Technology International LLLP, the NanoRobot-6AX combines an X-Y-Z 100-mm-travel-range nanopositioning platform with DTI’s RoboMate robotic...
DTI Nanotech (See Discovery Technology International)
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Avalanche photodiode Hamamatsu Corp. has introduced the S8664-1010 silicon avalanche photodiode that offers a large 10 x 10-mm active area, making it suitable for low-light-level measurement in analytical instruments....
Hamamatsu Corporation
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Cylindrical lens mounts Newport Corp. has announced the CYM-2R family of cylindrical lens mounts for managing light. They can hold and position cylindrical optics as large as 2 in. in height and, with the use of adapters,...
MKS/Newport
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Mirror mount Elliot Scientific Ltd. has launched the KML131 locking kinematic mirror mount for applications that require beam steering and locking. The device features stainless-steel adjusters with brass...
Elliot Scientific Ltd.
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FTIR microscope Jasco Inc.’s Irtronμ sample compartment microscopy system is designed for the analysis of microscopic samples with the benefits of an external Fourier transform infrared microscope...
JASCO Inc.
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Virtual prototyping With enhanced features, Comsol Inc.’s Multiphysics 3.3 software is designed to bring simulation and virtual prototyping capabilities to a greater number of engineers. The release expands the...
COMSOL Inc.
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Sapphire laser optics Custom-fabricated sapphire laser optics are available from Meller Optics Inc. They include planoconvex, planoconcave and meniscus lenses, and windows, mirrors and wave plates. Sizes from 1/4- to...
Meller Optics Inc.
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BIOPHOTONICS 2006
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