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BioPhotonics: May 2006

BioPhotonics
 May 2006


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FEATURES
Creating Clarity: Adaptive Optics for Bioimaging Biological imaging instruments often have resolution limitations that restrict the ability of researchers and clinicians to detect critical detail. One reason is that, as light passes through tissue to reach the object of interest — a cell, the retina or a tumor — the tissue induces wavefront aberrations in the light. Adaptive optics can actively correct these aberrations in the...
Camera Phones Emerge as a Health Care Tool Telemedicine gives patients access to a doctor no matter where they are. Whether a patient uses monitoring equipment to send information to the doctor’s office or an x-ray technician transmits...
Focusing on the Experiment For Alexey Khodjakov, a researcher at the New York State Department of Health’s Wadsworth Center in Albany, it wasn’t a question of if but when he would lose focus. Following cells as...
RAPIDSCAN
‘Cold lights’ in the summer night sky Fireflies communicate with one another with flashes of light. Investigators have long been intrigued by this process, especially because the insects emit the light without generating heat. Although...
Exploring the evolution of sight Lizards and several other lower vertebrates have a third, or parietal, eye. Whereas their other two eyes provide high-level visual functions such as image processing, this evolutionary vestige...
Modified GFP enables in vivo imaging of cellular signaling in the heart The efficient functioning of the heart — an organ that begins to operate before it is fully developed — depends on the coordinated release and reuptake of calcium ions from organelles...
Adjustable lenses may mean no more bifocals Along with thinning hair, a few more wrinkles and some added pounds, by age 50 nearly everyone notices that print seems harder to read. It’s the result of presbyopia, an age-related inability...
Real-time imaging during centrifugation People who lose blood or whose bodies aren’t producing enough can receive transfusions. However, they sometimes need only certain blood components, such as red blood cells, plasma and...
Laser-activated bubbles mitigate toil and troubles A number of biomedical applications take advantage of laser light interactions with tissue that are accompanied by absorption of light by tissue. As the absorbed energy converts into heat, it...
Miniature 2-D flow cytometer Conventional flow cytometers are large and expensive and usually provide one-dimensional data, but two-dimensional data is needed for detecting subtle differences in the morphology of cells....
Whirling-fiber endoscope allows two-photon imaging Two-photon imaging could be a useful medical technique if a suitable in vivo probe were available. Such a probe must be capable of rapidly scanning across a reasonably large area, and it must...
Molecular Devices Corp. Molecular Devices Corp. of Sunnyvale has purchased the laser capture microdissection business of Arturus Bioscience Inc. of Mountain View, both in California, for $10 million. The acquisition...
Schott North America Schott North America of Duryea, Pa., has secured $1 million in a defense appropriations bill for research and development of a fully automated system for detecting the presence of biological agents....
Fuji Photo Film Co. Ltd. Fuji Photo Film Co. Ltd. has invested $8.3 million in Perseus Proteomics Inc. Together, the Tokyo-based companies will focus on developing a medical material by combining Fuji’s proprietary...
Society of Nuclear Medicine The Society of Nuclear Medicine of Reston, Va., has developed a procedure guideline for using positron emission tomography (PET) and computed tomography (CT) to image tumors in adults and children....
Invitrogen Corp. Invitrogen Corp. of Carlsbad, Calif., has entered into an agreement with the National Institutes of Health Chemical Genomics Center in Bethesda, Md., to identify small molecules that modulate key...
MediSpectra Inc. MediSpectra Inc. of Lexington, Mass., has received FDA approval for the Luma cervical imaging system. When used in conjunction with colposcopy — for women who have had abnormal Pap test results...
Engineering and Physical Sciences Research Council The Engineering and Physical Sciences Research Council of Swindon, UK, and Philips Research of Best, the Netherlands, have formed an alliance to fund research and training in biomedical diagnostic...
Hologic Inc. Hologic Inc. of Bedford, Mass., has entered into an agreement to purchase Suros Surgical Systems Inc. of Indianapolis, a developer of devices used for minimally invasive biopsy and tissue excision....
Heidelberg Engineering GmbH The FDA has granted clearance to Heidelberg Engineering GmbH’s SL-OCT optical coherence tomography device for cross-sectional anterior segment imaging. The system, mounted on a slit lamp for...
Olympus America Inc. Olympus America Inc. of Melville, N.Y., has combined its Scientific Equipment and Diagnostic Systems Groups and Life Science Business Development unit to create the Life Science Group. The move is...
PerkinElmer Inc. PerkinElmer Inc. of Wellesley, Mass., and George Mason University of Fairfax, Va., have announced a five-year research collaboration to develop approaches for cancer detection and risk...
PhotoMedex Inc. PhotoMedex Inc. of Montgomeryville, Pa., has signed development, manufacturing and distribution contracts for the MetaSpex Laboratory System from AzurTec Inc. of Newtown, Pa. The light-based device...
Aperio Technologies Inc. Aperio Technologies Inc. of Vista, Calif., has secured an exclusive reseller license for Zoomify Inc.’s third-party Web viewing software. The program enables Internet viewing of...
Nidek Technologies America Nidek Technologies America, formerly of Greensboro, N.C., has joined Nidek Inc. in its Fremont, Calif., location. The move combines the clinical, development, distribution, marketing and sales...
P.A.L.M. Microlaser Technologies GmbH The application laboratory at P.A.L.M. Microlaser Technologies GmbH of Bernried, a subsidiary of Carl Zeiss MicroImaging GmbH of Jena, both in Germany, has been approved to perform processes...
Advanced Research Technologies Inc. Advanced Research Technologies Inc. of Saint-Laurent, Quebec, Canada, has announced clinical trials for the SoftScan optical breast imaging system. The device uses time-domain optical imaging to...
BD Biosciences BD Biosciences of San Jose, Calif., and Dynomics BV of Rotterdam, the Netherlands, have reached an agreement that grants the former an exclusive worldwide license to specific intellectual property...
Cynosure Inc. Cynosure Inc. of Westford, Mass., has received FDA approval for its pulse dye laser for the treatment of pigmented lesions, including freckles, solar lentigines, café au lait birthmarks, scars...
AS WE GO TO PRESS
Fluorescence technique detects diseases in blood Doctors can screen for infectious agents or diseases by looking for the presence of marker proteins. Immunological assays are often used for this, but they cannot detect a marker protein unless a certain amount of it is present in a blood sample. This means that sometimes the disease must already have progressed substantially to be detected. Researchers from the University of Pennsylvania in...
Blue light changes a fluorophore from green to red During the past several years, researchers have developed photoactivatable fluorescent proteins that are similar to GFP but that change color when introduced to UV-to-violet wavelengths....
Restoring vision with light-sensitive protein A loss of photoreceptor cells caused by retinal degenerative diseases often results in complete blindness. Zhuo-Hua Pan of Wayne State University School of Medicine in Detroit and colleagues explored...
Finally, a transgenic GFP Hydra Hydra freshwater polyps are important model organisms in environmental and conservation science and evolutionary developmental biology. Scientists study the organisms because they evolved ∋600...
Scientists successfully mimic insect eyes Imagine being able to see more than a 90° field of view without turning your head. Because of their compound eyes, insects can, but so far, only fish-eye lenses can artificially accomplish this,...
BREAKTHROUGHMEDIA
Assays, antibodies Vol. 15.2 of Chemicon Connection, a serial publication of Chemicon International, a Serologicals company, is organized by the following sections: nuclear function, cell culture, cancer, adhesion, neuroscience and biotools. It highlights new products, including antibodies for neuroscience research, nonradioactive transcription factor assays, screening tools for cell-extracellular matrix...
Hardware, positioners Melles Griot has added to its online catalog a full line of optomechanical hardware, including optical rail and mounting systems, controllers for nanometric positioning, high-resolution positioning...
Optical filters The updated Web site of Omega Optical Inc. features new graphics, including images of products and manufacturing, and galleries of images provided by life sciences collaborators. Among the...
Fluid sensors A literature package titled “Fluid Sensors for Medical OEMs” from Gems Sensors & Controls Inc. describes the company’s compact liquid level switches, flow and pressure sensors,...
Spectral libraries Thermo Electron Corp. has introduced a catalog featuring collections of FTIR and Raman spectral libraries that are specifically designed to work with its instruments and software. Useful to...
Optical systems Optical Insights, a designer, developer and manufacturer of optical systems for a variety of spectral and polarization imaging applications, has launched a Web site geared toward researchers and...
Spectral data Advanced Chemistry Development Inc. (ACD/Labs) has introduced Version 9 of its ACD/Web Librarian, Web browser-based software for sharing and viewing spectral, chromatographic and chemical data. Key...
LC/MS systems A seven-page brochure from Agilent Technologies Inc. presents the company’s 6000 series LC/MS systems, which include triple-quadrupole and quadrupole-time-of-flight (Tof) instruments, and...
Lab supplies The second edition of the SCP Science “Instruments & Supplies” catalog specifies new products for the inorganic chemical laboratory, including the PlasmaPure Plus high-purity acids, a...
Microfluidic tools A trifold brochure titled “Microfluidic Products from Micralyne” has been released by Micralyne Inc. It describes the user-configurable Microfluidic Tool Kit for electrophoresis-based...
Imaging methods Part of the “Methods Express” series, Cell Imaging covers key techniques that can be used in laboratories with access to cell imaging equipment. Although the 350-page book focuses on...
POSTSCRIPTS
’Netting’ a big collection of fish The Keck Center for Functional Magnetic Resonance Imaging is getting together with Scripps Institution of Oceanography to make available to the public — via the Internet — the latter’s world-class collection of fish. Two views of the sanguine (or bloody) frogfish (Antennarius sanguineus), a bottom-dwelling angler fish of the eastern Pacific, show how layers of a specimen...
PRODUCTS
Microplate reader The SpectraMax M5e, announced by Molecular Devices Corp., adds the ability to read Cisbio international’s HTRF assays to the company’s family of multidetection microplate readers. Based on a dual-monochromator reader, the system is suitable for fluorescence, time-resolved fluorescence, absorbance, fluorescence polarization and luminescence assays. It handles plates with six to 384...
Molecular Devices LLC
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EGF-based optical probe The IRDye 800CW EGF optical probe released by Li-Cor Biosciences facilitates in vitro ligand-binding assays, in vivo near-IR animal imaging, whole-organ imaging and tissue section assays. Composed of...
LI-COR Biosciences, Biotechnology
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FRET filters Omega Optical Inc. has introduced 10 filter sets for Förster resonance energy transfer (FRET) and fluorescence lifetime imaging applications. Each set comprises an excitation, a dichroic and a...
Omega Optical LLC
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50-mW solid-state laser Coherent Inc. has added a 50-mW, 488-nm, continuous-wave model to its Sapphire line of solid-state lasers. The laser is suitable for flow cytometry, confocal microscopy, genetic screening and drug...
Coherent Inc.
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Portable spectrometer Analytical Spectral Devices Inc. has introduced the LabSpec 2500/2600 series of portable VIS/NIR spectrometers, suitable for applications with solids, powders, slurries and liquids. The compact...
ASD Inc.
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Viscometry software ATS RheoSystems has unveiled version 6.0 of its RheoExplorer software package for viscometry applications. Designed to run under 32-bit Windows 2000 or XP, the updated program provides speed,...
ATS RheoSystems
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Disposable cuvettes FluoroVette Flowcells from ALine Inc. are low-volume disposable cuvettes for nanomolar-range fluorescence detection in solutions. An alternative to quartz cuvettes, they hold 50 μl of fluid and...
ALine Inc.
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4.5-W laser diode SemiNex Corp. has announced a laser diode with >4.5 W of optical power at 1550 nm. The single-semiconductor device is suitable for applications such as medical aesthetic procedures, lidar and...
SemiNex Corporation
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Microspectrophotometer Craic Technologies has released the QDI 2010 UV-VIS-NIR microspectrophotometer for analysis of microscopic biological systems. The device can measure samples as small as a micron by absorbance,...
CRAIC Technologies
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Mass spectrometry A detector for mass spectrometry applications, the Co-Axial BiPolar Time-of-Flight detector is being offered by Burle Electro Optics Inc. The detector combines the high temporal resolution of...
Photonis Technologies
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Diode-pumped lasers The SHG series diode-pumped CW, Q-switched lasers from NuLasers are for direct use or OEM components in equipment for bioinstrumentation, spectroscopy, imaging, inspection and metrology....
NuLasers Ltd.
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Microbial identification Bruker Daltonics Inc. has announced the Maldi BioTyper system for identification and classification of microorganisms. It analyzes the characteristic protein expression patterns of bacteria, yeasts...
Bruker Daltonics Inc.
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Vibration isolation A vibration isolation workstation for ultralow natural frequency applications from Kinetic Systems Inc. is suitable for analytical balances, cell injection, patch clamping, wafer probing, sensor...
Kinetic Systems Inc.
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RGB LED illuminator A computer-controlled RGB LED illuminator for transmitted light in upright microscopes is offered by Tofra Inc. The unit provides bright, uniform and diffuse light for near-Koehler illumination, and...
Tofra Inc.
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Laser ablation system The GeoLasPro from Coherent Inc. is a laser ablation system designed for the introduction of samples in laser ablation inductively coupled plasma mass spectrometry. It incorporates the CompPexPro...
Coherent Inc.
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Hard coatings, filters Foreal Spectrum Inc. has launched high-performance, ion-beam-sputtered hard coatings on single substrates, filters and components for biotechnological, analytical and laser instrumentation. The...
Foreal Spectrum Inc.
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Ti:sapphire conversion Trestles wavelength conversion units from Del Mar Photonics Inc. can be added to Ti:sapphire femtosecond laser systems and are suitable for microscopy and spectroscopy. The second harmonic generation...
Del Mar Photonics Inc.
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Illuminated microscope Carl Zeiss has announced that its entry-level Axio Imager.A1 microscope is available with an LED illumination system instead of conventional — and more costly — halogen lighting. The LED...
Carl Zeiss Ltd.
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Liquid level sensors The ELS-900 and -1150 electro-optic liquid level sensors from Gems Sensors & Controls Inc. is suitable for use in medical diagnostic, sterilizer, washer and dialysis equipment. The plastic...
Gems Sensors & Controls Inc.
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Emission spectrometer Shimadzu Scientific Instruments Inc. has unveiled the ICPE-9000 multitype induction-coupled plasma emission spectrometer for analysis of substances from metals to pharmaceuticals. Using a large-scale...
Shimadzu Scientific Instruments Inc.
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UV DPSS laser Spectra-Physics Lasers Div. has released the Explorer, a Q-switched, ultraviolet diode-pumped solid-state OEM laser system at 349 nm. It features a TEM00 output beam with M2<1.3. It is available...
Newport Spectra-Physics GmbH, Photonics Solutions Div.
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Monochromators McPherson Inc. offers multiple-pass double-dispersion accessory optics for its 0.67- to 2-m focal length monochromators, which achieve twice the resolution, a low f number and good light throughput,...
McPHERSON
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Yellow DPSS laser A yellow diode-pumped solid-state laser from CrystaLaser Inc. produces 60 mW of single-frequency output at 561 nm. The compact device provides a diffraction-limited TEM00 beam and <0.5% rms of...
CrystaLaser LC
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Stabilized lasers Lissotschenko Mikrooptik GmbH (Limo) has announced that its diode lasers can be ordered with technology to improve wavelength stabilization. The technology is integrated into each laser’s...
LIMO GmbH
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Fluorescence detection The H9797 series fluorescence detection assemblies from Hamamatsu Corp. enables simultaneous detection of multiple wavelengths for design into cell sorters, microtiter plate readers, gene scanners,...
Hamamatsu Corporation
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X-ray sensor Rad-icon Imaging Corp. has launched the Remote RadEye HR, a detachable, high-resolution x-ray sensor for compact x-ray imaging systems. The device contains a 2-D CMOS photodiode array with a 1200 x...
Teledyne Rad-icon Imaging
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Spectrometry software MassWorks is an easy-to-use postdata-acquisition software package from Cerno Bioscience. Combining proprietary MSIntegrity calibration technology and mathematical algorithms, the program improves...
Cerno Bioscience
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384-well microplates Porvair Sciences Ltd. has added to its line of low-volume 384-well microplates, which are now offered in black, white or clear polystyrene and are optimized for fluorescence. They provide a maximum...
Porvair Sciences Ltd.
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Raman spectrometer B&W Tek Inc. has introduced a Raman spectrometer that is suitable for portable analysis of biological, chemical and pharmaceutical materials. The battery-powered MiniRam collects Raman spectra...
B&W Tek LLC
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Five-axis optical mount A five-axis optical mount, the 5FAOM from Standa Ltd. holds 1-in. optics. It consists of a top-side regulation two-axis kinematic mirror mount, a two-axis translation stage with 2 mm of travel range...
STANDA UAB
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LED controllers Mightex Systems is offering Sirius Universal LED controllers, designed as general-purpose, multichannel drivers that can be used to drive any type of LED in constant-intensity, strobe or trigger...
Mightex Systems
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Optical inspection he Mantis Compact and Mantis Elite microscopes from Vision Engineering Inc. are eyepieceless optical inspection systems used for intricate tasks requiring high-resolution stereo viewing. They are...
Vision Engineering Inc.
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Rotary stage Nanomotion Inc. presents the R150 rotary stage for use in biomedical and pharmaceutical applications. The technology uses a proprietary ceramic servomotor based on ultrasonic standing waves for...
Nanomotion Inc.
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BIOPHOTONICS 2006
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