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BioPhotonics: December 2006

BioPhotonics
 December 2006


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Finding Photonic Ways to Monitor Blood Sugar Spectroscopic and fluorescence techniques might someday take the sting out of self-checking by diabetics. People afflicted with diabetes mellitus do not naturally produce enough insulin to process the sugars that they ingest into useful energy for their cells. Instead, they must regulate their sugar intake, increase their level of exercise and — if they are among the 5 to 10 percent of...
Frequency Division Multiplexed Fluorescence Confocal Microscopy High-speed, multichannel fluorescence confocal imaging can be achieved by encoding the spatial location information into the frequency domain. Fluorescence confocal microscopy is an important tool...
New Tools and Methods Accelerate Drug Discovery and Development Microfluidics and optical imaging are bridging the productivity gap in drug development. The pharmaceutical industry is under intense pressure to improve the efficiency of drug discovery and...
RAPIDSCAN
Fluorophores emit white light Because intermolecular distances are small, Förster resonance energy transfer (FRET) measurements must be precise to determine whether molecules interact. Using a fluorophore that simultaneously...
Miniature endoscope captures 3-D images An ultraminiature endoscope that offers three-dimensional imaging and enough flexibility to reach particularly delicate regions of the body has been developed by researchers from Harvard Medical...
Imaging chemotherapy’s effects on the brain Breast cancer survivors who have endured mental fogginess and forgetfulness following chemotherapy can take some comfort in the fact that “chemo brain” has been validated as a condition....
Chemiluminescence gets a boost from microwaves Chemiluminescence-based methods of detecting biological processes at the cellular level work well because most samples do not generate unwanted luminescence that must be filtered out. Using these...
Technique creates “islands” to isolate optical energy in skin In 2005, Americans spent more than $300 million on almost 800,000 laser hair removal treatments, according to the American Society of Plastic Surgeons. Lasers also can be used to alter skin...
Raman spectroscopy detects bladder cancer To localize a tumor in the bladder, doctors routinely perform a cystoscopy, a procedure that involves inserting a lensed, lighted tube into a patient to enable their search for potentially cancerous...
GFP cages may lead to new robust fluorophores Collaborative work among research groups at the University of Genoa, the University of Parma, and the University of Milano-Bicocca, all in Italy, has demonstrated that polyelectrolyte cages can...
Photoacoustic detection shows its sensitive side Detection of metastasis often proves to be difficult, either because investigation comes too soon in the development of tumor cells or because the cells have begun to disseminate away from the...
MRI may directly detect neuronal electrical activity Functional MRI is a noninvasive neuroimaging method that indirectly measures neuronal electrical activity by tracing localized changes in blood flow, blood volume and oxygenation levels associated...
UVP Inc. UVP Inc. of Upland, Calif., will distribute low-light imaging standards for Lux biotechnology ltd. of Edinburgh, UK, exclusively in North America and nonexclusively in Europe. The standards are...
Hologic Inc. Hologic Inc., a provider of diagnostic and digital imaging systems directed toward women’s health, has dedicated a new European headquarters, service and parts depot, and training center in...
Invitrogen Corp. Invitrogen Corp. of Carlsbad, Calif., will acquire Phillipsburg, New Jersey-based Sentigen Holding Corp., a developer of bioassay systems, in a cash transaction valued at $3.37 a share, or...
Cynosure Inc. Cynosure Inc. has received FDA clearance for its Smartlipo system for laser-assisted lipolysis in which a laser fiber cannula is inserted into the skin and through the treatment area to cause fat...
The National Human Genome Research Institute The National Human Genome Research Institute has awarded more than $13 million in research grants to speed the development of techniques that will reduce the cost of DNA sequencing and expand the use...
Nikon Instruments Nikon Instruments of Melville, N.Y., and California Institute for Quantitative Biomedical Research have opened a core microscopy imaging center at the University of California, San Francisco, to...
Mercury Computer Systems Inc. Mercury Computer Systems Inc. of Chelmsford, Mass., and Brit Systems Inc. of Dallas have partnered to integrate and distribute the latter company’s radiological image management system. Under...
Siemens Medical Solutions Siemens Medical Solutions of Malvern, Pa., has received a letter of approval from the FDA for its syngo Lung computer-aided detection device, designed to assist radiologists in the detection of solid...
Liquidmetal Technologies Inc. In California, Liquidmetal Technologies Inc. of Lake Forest has entered into an exclusive licensing and development agreement with Biolase Technology Inc. of Irvine for medical lasers in the dental...
The Cooperative Institute for Coastal and Estuarine Environmental Technology The Cooperative Institute for Coastal and Estuarine Environmental Technology has awarded $270,274 to two researchers to develop a tool for improved detection of microalgae. Hugh MacIntyre, senior...
BioVision Technologies Inc. BioVision Technologies Inc. of Exton, Pa., a provider of scientific digital imaging products, has acquired the software code, distribution rights and specific assets related to IPLab for Macintosh...
Affymetrix Inc. Affymetrix Inc. of Santa Clara, Calif., has announced that NimbleGen Systems Inc. of Madison, Wis., has obtained a nonexclusive, worldwide license to a number of its patents covering the manufacture,...
Salvador Imaging Salvador Imaging of Colorado Springs, Colo., has entered into a $1.9 million contract to design and produce digital cameras for a leading veterinary x-ray imaging supplier. The cameras will be...
Millipore Corp. Millipore Corp., a provider of products and services for the improvement of productivity in the laboratory and in biopharmaceutical manufacturing, has opened a research and development center in...
NeuroMetrix Inc. NeuroMetrix Inc. of Waltham, Mass., a medical device company, has signed an exclusive licensing agreement with EyeTel Imaging Inc. of Columbia, Md. The agreement allows the Massachusetts company to...
Leica Microsystems GmbH Leica Microsystems GmbH of Wetzlar, Germany, has received approval from the FDA for its Leica FL800, a video angiogram device for viewing of intraoperative blood flow in the cerebral vascular area....
The NIH The NIH has completed its national network of eight Nanomedicine Development Centers as part of its nationwide Roadmap for Medical Research program. Staffed by multidisciplinary scientific teams that...
Bio-Rad Laboratories Inc. Bio-Rad Laboratories Inc. of Hercules, Calif., has announced its purchase of 2583%%Ciphergen Biosystems Inc.’s ProteinChip Systems business and rights to the Fremont, Calif., company’s...
Eastman Kodak Co. Eastman Kodak Co. has submitted the final clinical trial data and test results necessary for FDA premarket approval of its computed radiography (CR) system for mammography. The DirectView CR...
Fairway Medical Technologies Inc. Fairway Medical Technologies Inc. of Houston has received $3.8 million in federal funding to conduct Phase II research on optoacoustic breast and prostate cancer diagnostic methods. The NIH’s...
Olympus America Inc. Olympus America Inc. of Center Valley, Pa., has acquired the assets of New York/New Jersey Scientific Inc. of Middlebush, N.J., which distributes and resells scientific instruments. Olympus employees...
Andor Technology Andor Technology of Belfast, UK, has appointed 16468%%Gilden Photonics, also of the UK, as a distributor of its spectroscopy cameras and spectrographs within the UK.
LabSmith Inc. LabSmith Inc. of Livermore, Calif., has teamed up with Micronit Microfluidics BV of Enschede, the Netherlands, to offer complete solutions for microfluidics research. The cooperative effort brings...
AS WE GO TO PRESS
Nanoparticles target brain tumors Nanoparticles packed with high concentrations of a proven cancer-killing drug may provide a safer and more effective way to target brain tumors, researchers at the University of Michigan...
Grid technology enables electronic image sharing among hospitals Digital Imaging and Communications in Media (DICOM) standards have helped create a uniform format for x-ray, CT, MRI and other medical images. Although the standards ease image analysis, doctors who...
Mini mugs manufactured to hold microsamples The first time people order espresso, they are usually surprised at the dainty dimensions of the porcelain cup in which it is served. But those cups are huge compared with the ones created by...
Imaging the brain’s response to brand names Scientists have observed through functional MRI that well-known product brand names have a strong, positive effect on the human brain, independent of the type of product or service being offered. Led...
BREAKTHROUGHMEDIA
Biochip technology Geared toward bioengineers, biotechnologists, and pharmacological and general bench researchers, Frontiers in Biochip Technology is a collection of manuscripts written by experts on emerging...
Histological techniques The second edition of Cellular Pathology: An Introduction to Techniques and Applications is designed to serve as a textbook for students in biomedical science and other fields related to medicine. It...
Cell culture supplies Millipore Corp. has released its “Multiwell Products Guide,” which presents tools for drug discovery research and sample preparation. The 40-page resource includes information on the...
Molecular imaging An application overview titled “Molecular Imaging on the Odyssey” is available from Li-Cor Biosciences. The downloadable four-page, full-color brochure describes the Odyssey infrared...
Spectrophotometers Jasco Inc. has released a 12-page, full-color brochure that describes the features and benefits of its V-600 series UV-VIS/NIR spectrophotometers. Available in print and as a download, the document...
Biophotonics Book Optical technologies, including microscopy and spectroscopy methods, are described in Biophotonics: Visions for Better Health Care. The 621-page volume represents a three-year research program funded...
Clinical MRI The multimedia edition of Clinical Magnetic Resonance Imaging provides online access to the text and images of the three-volume, third-edition set, which is included in the package. The resource...
Optics Web sites The Optical Society of America has launched enhanced Web sites to represent both its organization and its magazine Optics & Photonics News (OPN). The OSA portal features streamlined navigational...
Cardiac CT Written for cardiologists and radiologists, Cardiac CT Imaging: Diagnosis of Cardiovascular Disease provides an overview of the use of computed tomography for assessing cardiac structure and...
Optics topics The book Optics: Principles and Applications is geared toward engineering and physics students and professionals, detailing topics such as holography, geometric optics, Fourier transforms, Fraunhofer...
POSTSCRIPTS
New insight into the cause of multiple sclerosis In multiple sclerosis, inflammation in the central nervous system leads to unsheathing of the protective myelin that coats neurons, causing them to degenerate. Scientists have thought that the inflammation is caused by an immune response directed against the myelin. New research lends credence to this belief by revealing certain specifics of how the immune response occurs. The work could help...
PRODUCTS
Digital camera Diagnostic Instruments Inc. has unveiled an enhanced Spot Xplorer XS digital camera system for biological imaging. Providing 14-bit megapixel images at up to 11 full frames per second, and as low as 4.5 e2 read noise for tracking rapid events, the system features dual-speed readout for maximum speed or lowest noise level. It delivers —42 °C regulated cooling for dark noise reduction and...
SPOT Imaging
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Perfusion system A miniature perfusion system for exchanging or applying test solutions to microscopic samples during imaging or recording has been released by Bioscience Tools. It features digital, analog and serial...
Bioscience Tools
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Fluorescence illumination The Lumen 200 fluorescence illumination system from Prior Scientific Inc. employs a 200-W metal arc lamp that lasts 2000 h. The lamp is precentered for easy installation. The light can be connected...
Prior Scientific Inc.
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Imaging systems The Spotlight 400 FT-IR and 400N FT-NIR imaging systems from PerkinElmer Inc. are designed to increase throughput and improve data quality of samples in laboratories that specialize in...
PerkinElmer Instruments
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Quantitative imaging The Lumazone imaging system from Roper Bioscience is offered in various models for quantitative measurements of chemiluminescence and fluorescence emitted by samples, including whole animals and...
Roper Bioscience
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Photodetector amplifier Opto Diode Corp. has announced the ODA-5W-100M photodetector amplifier combination with 100 megaohm gain, suitable for fluorescence, spectroscopy and low-light-level tasks where electrical noise can...
Opto Diode Corporation
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Electrophoresis software Bio-Rad Laboratories Inc. is offering security edition software and a validation kit for its Experion automated electrophoresis system targeted toward biotechnology and pharmaceutical companies....
Bio-Rad Laboratories Inc., Life Science Group
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Video imaging module Navitar Inc. has released a differential interference contrast module, a video imaging tool for inspecting semiconductor wafers, flat panel displays, diamonds, translucent biological samples and...
Navitar Inc.
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Nanoparticle counter NanoSight Ltd. has launched a bench-top system that rapidly and easily sizes and counts individual nanoscale particles in suspension. The system, NanoSight LM20, has newly developed software that...
NanoSight Ltd.
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Frame grabbers National Instruments has released three PCI Express-based frame grabbers, supporting major digital camera buses. Suitable for machine vision, the NI PCIe-8255R can acquire data from IEEE-1394a and...
National Instruments Corp.
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Programmable logic The LC220 programmable logic controller from LabSmith Inc. provides synchronization for lasers and laboratory apparatus. With Windows- or LabView-based programming, it can be operated while embedded...
LabSmith Inc.
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Photon counter Users of the id201 near-IR, single-photon detector from id Quantique SA can adjust the bias voltage, which controls detection efficiency. Photon detection probability at 1550 nm can be selected from...
ID Quantique
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PLL synchronization Toptica Photonics AG has added phase-locked-loop (PLL) synchronization electronics to its line of FemtoFiber scientific lasers. Femtosecond lasers now can be synchronized to synchrotrons,...
Toptica Photonics AG
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CMOS cameras The Go series digital color cameras from QImaging uses CMOS sensors and can be connected through a USB 2.0 interface. The cameras can be used for histological and pathological applications. The Go-3,...
Teledyne QImaging, Teledyne Imaging
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Magnetic beads Bruker Daltonics Inc. has launched the ready-to-use ClinProt MB, a lectin affinity chromatography-lens culinaris agglutinin kit for glycoprotein analysis and clinical proteomics research. The...
Bruker Daltonics Inc.
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Digital cameras Imperx Inc. has added two new cameras to its Lynx digital camera line. The IPX-16M3-G and the IPX-16M3-L offer fully programmable resolution, frame rate and exposure control. The cameras use a...
Imperx Inc.
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NIR spectrometer Avantes BV has unveiled the AvaSpec-NIR256 spectrometer, available with two InGaAs detector types — an uncooled version for applications up to 1.7 μm and a two-stage Peltier-cooled extended...
Avantes BV
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Photodiode detector A Geiger-mode avalanche photodiode detector that can detect ultralow-level light in a variety of applications has been introduced by Hamamatsu Corp. The S10362-11 series multipixel photon counter can...
Hamamatsu Corporation
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Software development kit The MultiCore Plus software development kit 1.0 is a suite of software products developed by Mercury Computer Systems Inc. for the Cell Broadband Engine and other multicore processors. Enabling users...
Mercury Systems Inc.
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UHPLC detector Jasco Inc. has developed a fluorescence detector for ultrahigh pressure liquid chromatography (UHPLC) applications. The XLC-3020FP provides excitation and emission stability over wavelengths from 220...
JASCO Inc.
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Medical laser Rofin/Baasel Lasertech has enhanced its StarCut Tube, a precision laser cutting system for making medical implants such as stents and other components. The system can cut an 8-mm coronary stent in...
Rofin-Baasel Lasertech
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High-power LED The Platinum Dragon LED manufactured by Osram GmbH can withstand twice the output as the Golden Dragon, providing a higher operating current and, therefore, more light. It produces white light at 75...
Osram Opto Semiconductors GmbH
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Microplate handling Molecular Devices Corp. has introduced the StakMax integrated microplate handling system, which can process up to 50 plates per batch, increasing productivity during experiments. The benchtop system...
Molecular Devices LLC
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Photon counter SUI, a division of Goodrich Corp., has released the SU-02-SPC NIR photon counter. The 19 x 5.25 x 12-in. bench instrument is designed for single-photon counting in the near-IR spectrum from 0.9 to...
Sensors Unlimited Inc. - A Collins Aerospace Company
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Fiber-coupled laser Pavilion Integration Corp. has expanded its WhisperIT product line with the addition of a fiber-coupled version of its miniature 532-nm laser module. The green laser is housed in the same compact...
Pavilion Integration Corp.
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Multi-purpose microscope Nikon Instruments Inc. has introduced the AZ100 Multizoom micro/macro imaging microscope for studies of subjects ranging in size from whole animals to single cells. The instrument features a wide...
Nikon Instruments Inc.
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Metrology gauges PI (Physik Instrumente) LP has announced the D-510 family of PISeca capacitive displacement gauges for nanometrology applications. They perform high-precision, noncontact measurements of geometric...
PI (Physik Instrumente) LP, Motion Control, Air Bearings, Piezo Mechanics
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BIOPHOTONICS 2006
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