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BioPhotonics: June 2006

BioPhotonics
 June 2006


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FEATURES
On the Path Toward More Useful Fluorophores Where would modern biomedical research be today without fluorescent probes? Some would argue that it would be blindly groping down a dark alley, with no efficient means of discovering the finely honed interplay of proteins and other substances in the human body, especially at the cellular and molecular levels. But such probes do exist, whether as dyelike molecules, artificial metallic dots...
Microscope Takes Deep-UV and Visible Picosecond Fluorescence Lifetime Measurements Time-resolved microscopy is the ultimate tool for investigating dynamic events in cells and subcellular structures. However, it previously was limited when used for applications that required...
Multispectral FLIM Enhances FRET Autofluorescence Imaging er the past decade, confocal and multiphoton laser scanning microscopy have become standard for biomedical imaging on the cellular level. Because these techniques either suppress or don’t...
Direct Proximity Imaging with FRET and FLIM Florescent proteins have opened the possibility to observe protein distribution and localization by fluorescence microscopy. Directly observing these nanometer-size molecules is not possible,...
Eye Tracking Helps Improve Accuracy in Radiology Improving the accuracy of radiology diagnostic reading is critical for a number of reasons. Greater accuracy means that a higher percentage of malignancies will be detected — and detected...
RAPIDSCAN
Gold stars offer new rewards The size- and shape-dependent emission of noble metal nanoparticles makes them useful for applications such as sensing and labeling and even for nanoscale optical waveguides. For sensing, these...
Faster confocal technique explores heart’s pumping mechanism in vivo The cardiovascular system is the first functional organ system to develop, and the embryonic heart begins pumping blood before features such as chambers and valves are discernible. Until recently,...
Fourier domain mode-locked frequency-swept laser speeds OCT Optical coherence tomography (OCT) may one day be faster and more accurate, thanks to a new type of laser mode-locking developed by researchers at MIT in Cambridge, Mass. The technique, called...
Twin-beam optical trapping spins cells Detecting the causes of cancer at its earliest stages would be of great help in fighting the disease. However, the sooner one tries to see the beginnings of tumor development, the less change is...
A simple alternative for ionization Organic salts include molecules such as proteins and lipids, which are critical for human health. Structural information on these molecules helps reveal more about the body’s function and aids...
Defocusing improves microscopic analysis of red blood cells Several years ago, Oscar N. Mesquita, a researcher with the Federal University of Minas Gerais in Belo Horizonte, Brazil, was measuring the movement of macrophages. At one point, he looked into the...
Acrongenomics Inc. Acrongenomics Inc. of Geneva and Molecular Visions Ltd. of London will combine efforts to develop and commercialize portable point-of-care diagnostic equipment for medical testing. Potential tests...
Hologic Inc. Hologic Inc. of Bedford, Mass., has entered into an agreement to buy R2 Technology Inc. of Sunnyvale, Calif., for $220 million in common stock. The latter company develops and commercializes...
Bruker BioSciences Corp. Bruker BioSciences Corp. has purchased molecular spectroscopy company Bruker Optics Inc., both of Billerica, Mass., for $135 million in cash and stock. The company will provide mass spectrometry,...
Dalsa Corp. Dalsa Corp. of Waterloo, Ontario, Canada, has received a CDN $1.5 million contract to develop CMOS image sensor chips for a dental x-ray equipment manufacturer. The chips enable the x-ray system to...
Fisher Biosciences Fisher Biosciences, a unit of Fisher Scientific International Inc. of Hampton, N.H., has purchased BioImage of Soeborg, Denmark, to enhance its high-content screening and analysis reagent technology...
Cleveland Clinic Lerner Research Institute The Cleveland Clinic Lerner Research Institute and Rensselaer Polytechnic Institute of Troy, N.Y., have signed an agreement to collaborate on research in several areas of biomedicine, including...
National Endowment for Science, Technology and the Arts The National Endowment for Science, Technology and the Arts of London has made a £30,000 seed investment in the Magnicap drug packaging concept. The project incorporates a small magnifying...
Society of Nuclear Medicine The Society of Nuclear Medicine of Reston, Va., and Bracco Diagnostics Inc. of Princeton, N.J., have inaugurated a $35,000 fellowship in cardiovascular molecular imaging to foster pilot research in...
TriPath Imaging Inc. TriPath Imaging Inc. of Burlington, N.C., has received the FDA’s 510(k) approval to use the Ki-67 cell proliferation biomarker with the Ventana Image Analysis System from Ventana Medical...
Fujitsu Ltd. Fujitsu Ltd. and Mitsui & Co. Ltd., both in Tokyo, have established QD Laser Inc., an optical device venture. Leveraging capital from both companies and quantum dot laser technology from Fujitsu,...
NASA NASA has awarded Boston Applied Technologies Inc. of Woburn, Mass., and The Catholic University of America of Washington, a Phase 2 Small Business Technology Transfer contract for their collaboration...
PerkinElmer Inc. PerkinElmer Inc. of Wellesley, Mass., has purchased the assets of Spectral Genomics Inc., a molecular karyotyping technology company in Houston. The acquisition includes products and analysis...
AS WE GO TO PRESS
Electron microscopy helps define HIV’s spikes On each particle of HIV, there are scattered several spikes — composed of glycoprotein — that initiate the infection of healthy cells. The glycoprotein is a candidate target for potential vaccines against the virus; however, little is known about the structure and distribution of the spikes. Now Ping Zhu and his colleagues at Florida State University in Tallahassee and at the National...
Gold beads help image eye movements Imaging methods such as MRI cannot capture movements of much of the eye’s orbit — the cone-shaped bony cavity that protects the eye. Because the movements of the eye’s muscles and...
Luminescent carbon dots provide nontoxic alternative to silicon Noting the toxicity and potential environmental hazard of silicon-based semiconductor quantum dots, researchers at Clemson University in South Carolina have created carbon nanodots with...
Tracking the infection of flies Although it is known that Wolbachia — a bacterial genus present in 20 to 80 percent of all insects — is transmitted from female hosts to their offspring through their germ line, it has...
How small can Sanger DNA sequencing go? Since the development of DNA sequencing, scientists have been trying to do it less expensively and with less sample. There are various ways to sequence DNA, but the Sanger method generates long and...
BREAKTHROUGHMEDIA
Peptide resource AnaSpec Inc. has released its catalog “Peptides 2006-2008,” which features amyloids, enzyme substrates and inhibitors, and FRET, dye-labeled and phosphopeptides. In the downloadable...
Immunology products The main section of the “2006 Immunology Catalog” from Bachem is divided into the categories of antibodies-immunoassays, 125I-labeled peptides and general accessories. Product listings...
BioMEMS, microdevices The “Press Monograph” series includes the 637-page volume Fundamentals of Bio MEMS and Medical Microdevices and is designed to serve as a text for a single semester course for senior...
Mass spectra database A software package for professionals in forensics, toxicology, national security and environmental science, the Wiley Registry of Mass Spectral Data, eighth edition, from John Wiley & Sons Inc....
Microfluidics The 374-page book Microfluidics for Biotechnology explores an approach to the study and manipulation of proteins, cells and macromolecules such as DNA, in vitro and in living organisms. Through...
Surface plasmons Available in print and electronic versions, the quarterly journal Plasmonics publishes peer-reviewed original articles on notable advances in the theory, physics and applications of surface plasmons...
Microplate resource A 62-page, full-color catalog from Porvair Sciences Ltd. specifies its microplates and instrumentation, including the Microlute and Maxilute solid-phase extraction systems; solid-, clear- and...
Fluid sensors site A Web site launched by Gems Sensors & Controls Inc. is designed to address the fluid sensing and control needs of medical equipment design engineers. The portal encompasses application...
POST SCRIPTS
A peek beneath the feathers The caged bird may know why it sings — but does it know how? In songbirds, sounds are generated by the syrinx — the avian analogue of the human larynx, situated at the lower end of the trachea. The tune-to-be is then modified by the vocal tract and emitted from the beak. Conventional wisdom has it that songbirds have rigid, pipelike vocal tracts and that, therefore, they can change...
PRODUCTS
Ultrafast laser accessories Newport Corp.’s Ultrafast Lasers Accessory Kits contain the equipment needed to route the oscillator or amplifier source to an ultrafast experiment. Complementing the Tsunami and Mai Tai laser oscillators and the Spitfire Pro amplifier, the kits include ultrafast mirrors, beamsplitters, wave plates, lenses optimized for 700 to 930 nm and optomechanical components. Their Suprema-N and Ultima...
MKS/Newport
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3-D digital display system Micro Vision Systems Inc. has released TrueVision 1000, a real-time, high-definition 3-D image capture and display system for stereomicroscopes. Its sensor module replaces eyepieces on a microscope...
TrueVision 3D Surgical
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Tunable laser systems Sacher Lasertechnik GmbH offers automatically tunable laser systems in Littman/Metcalf configuration, with a typical output power of 500 mW over a large tuning area. They provide fine tuning via a...
Sacher Lasertechnik GmbH
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Light system OptiGrid, a light system offered by Qioptiq Imaging Solutions, is available for use with the Olympus MVX10 MacroView Zoom microscope. The system provides imaging for high-contrast fluorescence, 2-D...
Qioptiq
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In-line detection Applied Analytics Inc. has launched its in-line method for determining the presence of impurities in 5-ethylidene-2-norbornene, which is used in the production of rubber and polymers for electronic...
Applied Analytics Inc.
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Digital CCD cameras New Electronic Technology (NET) GmbH has unveiled the S-series Foculus monochrome and color IEEE-1394 digital CCD cameras. The cameras achieve resolutions from 640 x 480 at up to 86 fps and from 1600...
NET New Electronic Technology GmbH
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Beam steering mirrors Alpine Research Optics (ARO) Corp. has produced two series of mirrors intended for beam steering tasks in Ti:sapphire ultrafast laser applications. The B-Max series mirrors have coatings optimized to...
Alpine Research Optics
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Cell-based server Mercury Computer Systems Inc. has released the 1U Dual Cell-Based Server for high-performance computing. The server delivers 410 GFLOPS in a rack-mountable 1U server, suitable for compute-intensive...
Mercury Systems Inc.
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Aspheric optics Edmund Optics has introduced Tech-Spec precision aspheric lenses with clear apertures from 15 to 25 mm and effective focal lengths from 11.25 to 37.5 mm. The components, available off the shelf, are...
Edmund Optics Inc.
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532-nm DPSS laser Cobolt AB has enhanced the performance of Samba, a diode-pumped solid-state laser that operates at 532 nm. Besides providing 25-, 50- or 100-mW CW output, the single longitudinal-mode laser now...
Cobolt AB
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Scanning technology Patent-pending intelligent scanning technology from Prior Scientific Inc. has been added to the ProScan II series motorized scanning stages. Each stage is programmed with its own set of operating...
Prior Scientific Inc.
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Materials screening The D8 Screenlab screening system integrates Bruker AXS Inc.’s D8 Discover two-dimensional x-ray diffraction system and Bruker Optics Inc.’s Raman probe. Introduced by the two companies,...
Bruker AXS Inc.
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Fluorescent light sources Olympus Life and Material Science Europa GmbH has released the Exfo X-Cite 120 PC automated light source for use with fluorescence microscopy. The adjustment-free 120-W metal-halide illuminator has a...
Olympus Europa SE & Co. KG
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Image sensors Hamamatsu Corp. has introduced the S9972 and S9973 series front-illuminated full-frame-transfer CCDs, which are suitable for low-light-level detection in applications such as spectrometry,...
Hamamatsu Corporation
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Translation stages PI (Physik Instrumente) LP offers a translation/rotation stage family that delivers 50-nm minimum incremental motion. With a 62 x 60-mm footprint, the M-110 series translation stages provide linear...
PI (Physik Instrumente) LP, Motion Control, Air Bearings, Piezo Mechanics
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Ultrafast oscillator Spectra-Physics, a division of Newport Corp., has unveiled the Tsunami HP ultrafast oscillator with a tuning range of 700 to 1080 nm. The oscillator provides flexibility and extends further into the...
Newport Spectra-Physics GmbH, Photonics Solutions Div.
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Refractive index detector Based on semiconductor photodiode technology and proprietary computer algorithms, the Optilab rEX refractive index detector from Wyatt Technology Corp. can measure the absolute refractive index of a...
Wyatt Technology Corp.
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Disease detection A sensing system for the detection of infectious diseases, such as SARS and the avian influenza, has been introduced by Armstrong Optical Ltd. Designed to inspect moving crowds of people for those...
Armstrong Optical Ltd.
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Remote microscopy JEOL USA Inc. has announced Sirius, a control system that enables the remote operation of a transmission electron microscope via a cellular Internet connection. With an instrument control knob and a...
JEOL USA Inc.
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BIOPHOTONICS 2006
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